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盐酸四咪唑

盐酸四咪唑用途

Tetramisole盐酸盐抑制碱性磷酸酶, 是一种高纯度的抗寄生虫。

盐酸四咪唑名称

[ CAS 号 ]:
5086-74-8

[ 中文名 ]:
四咪唑盐酸盐

[ 英文名 ]:
Tetramisole hydrochloride

[中文别名 ]:

盐酸四咪唑

[英文别名 ]:

mcn-jr 8299
levamisole hydrochloride
Tetramisole HCl
levamisole HCl
(±)-Tetramisole hydrochloride
orovermol
EINECS 225-799-5
MFCD00005536
McN-JR 8299-11
anthelvet

盐酸四咪唑生物活性

[ 描述 ]:

Tetramisole盐酸盐抑制碱性磷酸酶, 是一种高纯度的抗寄生虫。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 感染

[相关活性小分子]

盐酸四咪唑物理化学性质

[ 沸点 ]:
344.4ºC at 760 mmHg

[ 熔点 ]:
266-267ºC

[ 分子式 ]:
C₁₁H₁₃ClN₂S

[ 分子量 ]:
240.752

[ 闪点 ]:
162.1ºC

[ 精确质量 ]:
240.048798

[ PSA ]:
40.90000

[ LogP ]:
2.32160

[ 外观性状 ]:
白色至淡奶油色结晶粉末

[ 储存条件 ]:
室温

[ 水溶解性 ]:
200 g/L (20 ºC)

盐酸四咪唑MSDS

盐酸四咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5950000

CHEMICAL NAME :: Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (+-)-

CAS REGISTRY NUMBER :: 5086-74-8

LAST UPDATED :: 199306

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C11-H12-N2-S.Cl-H

MOLECULAR WEIGHT :: 240.77

WISWESSER LINE NOTATION :: T55 AN DN FS DUTJ CR &GH -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,602,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 958 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(5),64,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 450 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970

盐酸四咪唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NJ5950000

[ 海关编码 ]:
2934999090

盐酸四咪唑合成路线

盐酸四咪唑上下游产品

盐酸四咪唑上游产品

盐酸四咪唑下游产品

盐酸四咪唑海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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