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原卟啉钠

原卟啉钠用途

用作研究中荧光光谱表征的染料含量。在一项研究中报道了PpIX对肉瘤180实体瘤细胞的细胞毒性作用。

原卟啉钠名称

[ CAS 号 ]:
50865-01-5

[ 中文名 ]:
原卟啉钠

[ 英文名 ]:
Disodium protoporphyrin IX

[中文别名 ]:

[英文别名 ]:

EINECS 256-815-9
MFCD00151108
Disodium protoporphyrin IX
Protoporphyrin DisodiuM Salt

原卟啉钠物理化学性质

[ 沸点 ]:
1128.9ºC at 760 mmHg

[ 分子式 ]:
C₃₄H₃₂N₄Na₂O₄

[ 分子量 ]:
606.622

[ 闪点 ]:
636.6ºC

[ 精确质量 ]:
606.221924

[ PSA ]:
136.56000

[ LogP ]:
1.37120

[ 外观性状 ]:
紫色至栗色至棕色粉末

[ 储存条件 ]:
2-8°C

原卟啉钠MSDS

详细MSDS(安全技术说明书)

原卟啉钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TS5450000

CHEMICAL NAME :: 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, disodium salt

CAS REGISTRY NUMBER :: 50865-01-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C34-H32-N4-O4.2Na

MOLECULAR WEIGHT :: 606.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1192,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1029 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1147 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 484 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982

原卟啉钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
TS5450000

原卟啉钠文献

Protein structure. Structure and activity of tryptophan-rich TSPO proteins.

Science 347(6221) , 551-5, (2015)

Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs have tryptophan-rich seque...

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.

Nat. Med. 19(4) , 418-20, (2013)

Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that c...

Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity.

Mol. Pharmacol. 84(6) , 824-33, (2013)

Salicylic acid is a classic nonsteroidal anti-inflammatory drug. Although salicylic acid also induces mitochondrial injury, the mechanism of its antimitochondrial activity is not well understood. In t...

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