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原卟啉

原卟啉用途

Protoporphyrin IX是血红素生物合成途径中的最终中间体。

原卟啉名称

[ CAS 号 ]:
553-12-8

[ 中文名 ]:
原卟啉

[ 英文名 ]:
Protoporphyrin IX

[中文别名 ]:

[英文别名 ]:

Kammerer's prophyrin
MFCD00151109
protoporphyrin
EINECS 209-033-7
Kammerer's porphyrin
protoporphyrin-IX
Protoporphyrin IX

原卟啉生物活性

[ 描述 ]:

Protoporphyrin IX是血红素生物合成途径中的最终中间体。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Yasushi Nakai, et al.Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.

[相关活性小分子]

原卟啉物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1122.0±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₄H₃₄N₄O₄

[ 分子量 ]:
562.658

[ 闪点 ]:
632.4±34.3 °C

[ 精确质量 ]:
562.257996

[ PSA ]:
130.90000

[ LogP ]:
7.33

[ 外观性状 ]:
Powder | purple

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.674

[ 储存条件 ]:
2-8°C

原卟啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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原卟啉文献

Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.

Br. J. Cancer 111(5) , 874-82, (2014)

Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of ...

Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage.

Chem. Biol. Interact. 221 , 77-87, (2014)

The clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with adverse effects in the kidney. Indomethacin, an NSAID that has been shown to induce oxidative stress in the ...

Comparison of protoporphyrin IX produced cell proliferation inhibition between human breast cancer MCF-7 and MDA-MB-231 cells.

Pharmazie 69(8) , 621-8, (2014)

Protoporphyrin IX (PpIX) is an effective hematoporphyrin derivative, widely adopted in photodynamic therapy (PDT) and sonodynamic therapy (SDT). As a sensitizer, PpIX could significantly enhance laser...

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