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7-(二乙氨基)香豆素-3-甲酸

7-(二乙氨基)香豆素-3-甲酸用途

7ACC1(DEAC; Coumarin D 1421; D 1421)能选择性干扰肿瘤微环境乳酸通量,能抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入,但对乳酸流出无影响。

7-(二乙氨基)香豆素-3-甲酸名称

[ CAS 号 ]:
50995-74-9

[ 中文名 ]:
7-(二乙基氨基)香豆素-3-羧酸

[ 英文名 ]:
7-Diethylaminocoumarin-3-carboxylic acid

[中文别名 ]:

[英文别名 ]:

7-diethylaminocoumarin-3-carboxylic acid
7-(Diethylamino)coumarin-3-carboxylic Acid
7-(diethylamino)-2-oxochromene-3-carboxylic acid
7ACC1

7-(二乙氨基)香豆素-3-甲酸生物活性

[ 描述 ]:

7ACC1(DEAC; Coumarin D 1421; D 1421)能选择性干扰肿瘤微环境乳酸通量,能抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入,但对乳酸流出无影响。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 单羧酸转运蛋白

研究领域 >> 癌症

[参考文献]

[1]. Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8.

[相关活性小分子]

AZD3965 | 2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸 | (S)-6-[(3,5-二甲基-1H-吡唑-4-基)甲基]-5-[(4-羟基异唑烷-2-基)羰基]-1-异丁基-3-甲基噻吩并[2,3-D]嘧啶-2,4(1H,3H)-二酮 | 7ACC2

7-(二乙氨基)香豆素-3-甲酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
464.7±45.0 °C at 760 mmHg

[ 熔点 ]:
222-224ºC (dec.)(lit.)

[ 分子式 ]:
C₁₄H₁₅NO₄

[ 分子量 ]:
261.273

[ 闪点 ]:
234.9±28.7 °C

[ 精确质量 ]:
261.100098

[ PSA ]:
70.75000

[ LogP ]:
3.34

[ 外观性状 ]:
固体;Light yellow to Brown powder to crystal

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
存放于惰性气体之中;避免光,湿气 (分解)

7-(二乙氨基)香豆素-3-甲酸MSDS

7-(二乙氨基)香豆素-3-甲酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

7-(二乙氨基)香豆素-3-甲酸合成路线

7-(二乙氨基)香豆素-3-甲酸上下游产品

7-(二乙氨基)香豆素-3-甲酸上游产品

7-(二乙氨基)香豆素-3-甲酸下游产品

7-(二乙氨基)香豆素-3-甲酸海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-(二乙氨基)香豆素-3-甲酸文献

Photophysical properties of 7-(diethylamino)coumarin-3-carboxylic acid in the nanocage of cyclodextrins and in different solvents and solvent mixtures.

Photochem. Photobiol. , (2012)

The photophysical properties of 7-(diethylamino) coumarin-3-carboxylic acid (7-DCCA) were studied in cyclodextrins (α, β, γ,-CDs), different neat solvents and solvent mixtures by using steady state ab...

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid.

J. Biol. Chem. 276(27) , 24985-90, (2001)

GM1 ganglioside-bound amyloid beta-protein (GM1/Abeta), found in brains exhibiting early pathological changes of Alzheimer's disease (AD) including diffuse plaques, has been suggested to be involved i...

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid.

Biochemistry 41(23) , 7385-90, (2002)

GM1 ganglioside-bound amyloid beta-protein (GM1-Abeta), found in brains exhibiting early pathological changes of Alzheimer's disease (AD) plaques, has been suggested to accelerate amyloid fibril forma...

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