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安西奈德

安西奈德用途

Amcinonide抑制NO从活化的小胶质细胞释放, IC50 为3.38 nM, 具有糖皮质激素受体亲和力。

安西奈德名称

[ CAS 号 ]:
51022-69-6

[ 中文名 ]:
安西奈德

[ 英文名 ]:
Amcinonide

[英文别名 ]:

Amcinonid
Penticort
Amicla
cyclocort
Visderm
Amcinopol
Amciderm
AMCINONIDE

安西奈德生物活性

[ 描述 ]:

Amcinonide抑制NO从活化的小胶质细胞释放, IC50 为3.38 nM, 具有糖皮质激素受体亲和力。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Hong J, et al. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):912-918.

[2]. Berman B, et al. Modulation of expression of epidermal Langerhans cell properties following in situ exposure to glucocorticosteroids. J Invest Dermatol. 1983 Mar;80(3):168-171.

[3]. Quevedo WC Jr, et al. Influence of depigmenting chemical agents on hair and skin color in yellow (pheomelanic) and black (eumelanic) mice. Pigment Cell Res.1990 Mar-Apr;3(2):71-79.

[相关活性小分子]

安西奈德物理化学性质

[ 密度 ]:
1.33 g/cm3

[ 沸点 ]:
635.9ºC at 760 mmHg

[ 分子式 ]:
C₂₈H₃₅FO₇

[ 分子量 ]:
502.57200

[ 闪点 ]:
338.4ºC

[ 精确质量 ]:
502.23700

[ PSA ]:
99.13000

[ LogP ]:
3.52380

[ 外观性状 ]:
白色至淡黄色粉末

[ 折射率 ]:
1.586

[ 储存条件 ]:
室温

安西奈德毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3682500

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-flu oro- 11-hydroxy-, (11-beta,16-alpha)-

CAS REGISTRY NUMBER :: 51022-69-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C28-H35-F-O7

MOLECULAR WEIGHT :: 502.63

WISWESSER LINE NOTATION :: T F5 E5 B666 GOXO RV AHTTTT&J A1 BF CQ E1 FV1OV1 H-& AL5XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-1,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 243 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-1,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 896 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9371 No. of Facilities: 13 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 7645 (estimated) No. of Female Employees: 7200 (estimated)

安西奈德安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
TU3682500

安西奈德文献

Contact allergy to amcinonide.

Contact Dermatitis 15(2) , 109-11, (1986)

Trypsin inhibitors inhibit induction by interferon-gamma of HLA-DR antigen expression on human skin cells.

Exp. Cell Res. 183(1) , 215-28, (1989)

Serine protease inhibitors with a specificity for trypsin inhibit interferon-gamma (INF-gamma)-induced HLA-DR expression on a hybrid human epidermal cell line (H12), dermal fibroblasts, and primary ke...

Selective corticosteroid injection into the extensor pollicis brevis tenosynovium for de Quervain's disease.

Orthopedics 25(1) , 68-70, (2002)

Selective corticosteroid injection into the extensor pollicis brevis tenosynovium was performed in 50 patients (7 men and 43 women; 53 hands) with de Quervain's disease. Mean patient age was 32.4 year...

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