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替扎尼定

替扎尼定用途

Tizanidine是α2-肾上腺素受体激动剂,能抑制神经递质从CNS去甲肾上腺素激活的神经元中释放。

替扎尼定名称

[ CAS 号 ]:
51322-75-9

[ 中文名 ]:
替扎尼定

[ 英文名 ]:
Tizanidine

[中文别名 ]:

[英文别名 ]:

Sirdalud
Ternelin
[14C]-Tizanidine
Tizanidina [INN-Spanish]
Zanaflex(R)
Tizanidina
MFCD00798231
Tizanidinum
Zanaflex
UNII-6AI06C00GW

替扎尼定生物活性

[ 描述 ]:

Tizanidine是α2-肾上腺素受体激动剂,能抑制神经递质从CNS去甲肾上腺素激活的神经元中释放。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[参考文献]

[1]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39.

[相关活性小分子]

替扎尼定物理化学性质

[ 密度 ]:
1.82 g/cm3

[ 沸点 ]:
391.2ºC at 760 mmHg

[ 熔点 ]:
221 - 223ºC

[ 分子式 ]:
C₉H₈ClN₅S

[ 分子量 ]:
253.71100

[ 闪点 ]:
190.4ºC

[ 精确质量 ]:
253.01900

[ PSA ]:
90.44000

[ LogP ]:
1.55320

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
-20℃

[ 水溶解性 ]:
H2O: ~29 mg/mL

替扎尼定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL0080000

CHEMICAL NAME :: 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-

CAS REGISTRY NUMBER :: 51322-75-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H8-Cl-N5-S

MOLECULAR WEIGHT :: 253.73

WISWESSER LINE NOTATION :: T56 BNSNJ FM- BT5M CN BUTJ& GG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 235 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980

替扎尼定安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ WGK德国 ]:
3

[ RTECS号 ]:
DK9910000

[ 海关编码 ]:
2934999090

替扎尼定海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%