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二水合盐酸纳洛酮

二水合盐酸纳洛酮用途

Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.

二水合盐酸纳洛酮名称

[ CAS 号 ]:
51481-60-8

[ 中文名 ]:
二水合盐酸纳洛酮

[ 英文名 ]:
Naloxone hydrochloride dihydrate

[中文别名 ]:

盐酸纳洛酮二水合物

[英文别名 ]:

EINECS 206-611-0
MFCD00150901
Naloxone HCl Dihydrate
Naloxone hydrochloride dihydrate

二水合盐酸纳洛酮物理化学性质

[ 熔点 ]:
182 °C (dec.)(lit.)

[ 分子式 ]:
C₁₉H₂₆ClNO₆

[ 分子量 ]:
399.866

[ 闪点 ]:
288.4ºC

[ 精确质量 ]:
399.144867

[ PSA ]:
88.46000

[ LogP ]:
1.91270

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.

二水合盐酸纳洛酮MSDS

详细MSDS(安全技术说明书)

二水合盐酸纳洛酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

二水合盐酸纳洛酮文献

Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.

Toxicol. Appl. Pharmacol. 283(1) , 42-9, (2015)

There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of...

Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.

Life Sci. 92(23) , 1138-44, (2013)

In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between ...

Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis.

PLoS ONE 10 , e0125147, (2015)

Tramadol is thought to modulate synaptic transmissions in the spinal dorsal horn mainly by activating µ-opioid receptors and by inhibiting the reuptake of monoamines in the CNS. However, the precise m...

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