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N-Boc-1,6-二氨基己烷

N-Boc-1,6-二氨基己烷用途

NH2-C6-NH-Boc 是一种 PROTAC 连接桥 (PROTAC linker),属于 alkyl/ether 类。NH2-C6-NH-Boc 是可以用于基于 PROTAC 技术的 Mcl-1 抑制剂。

N-Boc-1,6-二氨基己烷名称

[ CAS 号 ]:
51857-17-1

[ 中文名 ]:
N-Boc-1,6-己二胺

[ 英文名 ]:
NH2-C6-NH-Boc

[中文别名 ]:

[英文别名 ]:

N-(tert-Butoxycarbonyl)-1,6-diaminohexane
N-Boc-1,6-hexanediamine
tert-Butyl (6-aminohexyl)carbamate
N-Boc-1,6-Diaminohexane
N-(6-Aminohexyl)carbamic Acid tert-Butyl Ester
tert-butyl N-(6-aminohexyl)carbamate
MFCD00671489
2-Methyl-2-propanyl (6-aminohexyl)carbamate
N-(tert-Butoxycarbonyl)-1,6-hexanediamine

N-Boc-1,6-二氨基己烷生物活性

[ 描述 ]:

NH2-C6-NH-Boc 是一种 PROTAC 连接桥 (PROTAC linker),属于 alkyl/ether 类。NH2-C6-NH-Boc 是可以用于基于 PROTAC 技术的 Mcl-1 抑制剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[参考文献]

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.

N-Boc-1,6-二氨基己烷物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
325.3±25.0 °C at 760 mmHg

[ 分子式 ]:
C₁₁H₂₄N₂O₂

[ 分子量 ]:
216.320

[ 闪点 ]:
150.5±23.2 °C

[ 精确质量 ]:
216.183777

[ PSA ]:
64.35000

[ LogP ]:
1.82

[ 外观性状 ]:
透明淡黄色粘性液体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.460

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免空气,加热

N-Boc-1,6-二氨基己烷MSDS

N-Boc-1,6-二氨基己烷安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2924199090

N-Boc-1,6-二氨基己烷合成路线

N-Boc-1,6-二氨基己烷上下游产品

N-Boc-1,6-二氨基己烷上游产品

N-Boc-1,6-二氨基己烷下游产品

N-Boc-1,6-二氨基己烷海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-Boc-1,6-二氨基己烷文献

Carboxymethylcellulose-tetrahydrocurcumin conjugates for colon-specific delivery of a novel anti-cancer agent, 4-amino tetrahydrocurcumin.

Eur. J. Pharm. Biopharm. 88(2) , 351-60, (2014)

Several curcumin derivatives are now becoming increasingly of interest because of their bioactive attributes, especially their action as antioxidants and anti-carcinogenic activities. Tetrahydrocurcum...

Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.

J. Med. Chem. 32 , 391, (1989)

We report the synthesis and biological activity of a series of analogues of the vasopressin antagonists [Pmp1,D-Tyr(Et)2,Val4]arginine-vasopressin (1) and [Pmp1,D-Tyr(Et)2,Val4,desGly9]arginine-vasopr...

O. Buchardt et al.

J. Org. Chem. 49 , 4123, (1984)

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