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N,N'-六亚甲基双乙酰胺

N,N'-六亚甲基双乙酰胺用途

六亚甲基二乙酰胺是一种肿瘤细胞分化剂[1]。

N,N'-六亚甲基双乙酰胺名称

[ CAS 号 ]:
3073-59-4

[ 中文名 ]:
N,N′-六亚甲基双乙酰胺

[ 英文名 ]:
Hexamethylene bisacetamide

[中文别名 ]:

[英文别名 ]:

N,N‘-Hexamethylenebisacetamide
N,N'-hexamethylene bis(acetamide)
Hexamethylenediacetamide
N,N'-diacetyl-1,6-hexanediamine
hmba
N,N′-Diacetyl-1,6-diaminohexane
diacetyldiaminohexane
EINECS 211-363-1
hexamethylenebis(acetamide)
N,N-Hexamethylenediacetamide

N,N'-六亚甲基双乙酰胺生物活性

[ 描述 ]:

六亚甲基二乙酰胺是一种肿瘤细胞分化剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Reuben RC, et al. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):862-6.

N,N'-六亚甲基双乙酰胺物理化学性质

[ 密度 ]:
0.974 g/cm3

[ 沸点 ]:
456.7ºC at 760 mmHg

[ 熔点 ]:
128-129 °C(lit.)

[ 分子式 ]:
C₁₀H₂₀N₂O₂

[ 分子量 ]:
200.28

[ 闪点 ]:
193.2ºC

[ 精确质量 ]:
200.15200

[ PSA ]:
58.20000

[ LogP ]:
1.60080

[ 外观性状 ]:
白色片状

[ 储存条件 ]:
室温，干燥

N,N'-六亚甲基双乙酰胺MSDS

详细MSDS(安全技术说明书)

N,N'-六亚甲基双乙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC2976200

CHEMICAL NAME :: Acetamide, N,N'-hexamethylenebis-

CAS REGISTRY NUMBER :: 3073-59-4

BEILSTEIN REFERENCE NO. :: 1775764

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H20-N2-O2

MOLECULAR WEIGHT :: 200.32

WISWESSER LINE NOTATION :: 1VM6MV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4270 mg/kg/10D-C

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - thrombocytopenia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5788,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

N,N'-六亚甲基双乙酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R33:Danger of cumulative effects.

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AC2976200

[ 海关编码 ]:
2924199090

N,N'-六亚甲基双乙酰胺上下游产品

N,N'-六亚甲基双乙酰胺上游产品

N,N'-六亚甲基双乙酰胺下游产品

N,N'-六亚甲基双乙酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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