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橙皮苷

橙皮苷用途

Hesperidin (HP)是一个生物类黄酮,具有生物和药理属性是一种有效的抗氧化,抗炎,抗癌,与降脂降压代理活动。

橙皮苷名称

[ CAS 号 ]:
520-26-3

[ 中文名 ]:
橙皮苷

[ 英文名 ]:
Hesperidin

[中文别名 ]:

[英文别名 ]:

usafcf-3
VITAMIN P
Hespeidin
Hespiridin
Hesperiden
Neobiletin
cirantin
MFCD00075663
Hesperetin7-rutinoside
Cirontin

橙皮苷生物活性

[ 描述 ]:

Hesperidin (HP)是一个生物类黄酮,具有生物和药理属性是一种有效的抗氧化,抗炎,抗癌,与降脂降压代理活动。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 黄酮类化合物

研究领域 >> 癌症

[参考文献]

[1]. Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493.

[2]. Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97.

[3]. Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682.

[4]. Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.

[相关活性小分子]

橙皮苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
930.1±65.0 °C at 760 mmHg

[ 熔点 ]:
250-255 °C (dec.)(lit.)

[ 分子式 ]:
C₂₈H₃₄O₁₅

[ 分子量 ]:
610.561

[ 闪点 ]:
305.5±27.8 °C

[ 精确质量 ]:
610.189758

[ PSA ]:
234.29000

[ LogP ]:
1.78

[ 外观性状 ]:
淡棕色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
存放于惰性气体之中;避免空气

橙皮苷MSDS

详细MSDS(安全技术说明书)

橙皮苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MK6650000

CHEMICAL NAME :: Hesperidin

CAS REGISTRY NUMBER :: 520-26-3

BEILSTEIN REFERENCE NO. :: 0075140

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C28-H34-O15

MOLECULAR WEIGHT :: 610.62

WISWESSER LINE NOTATION :: T66 BO EVT&J CR CQ DO1& GQ IO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1 GLUCO RHAMNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84694 No. of Facilities: 156 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 8654 (estimated)

橙皮苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MK6650000

橙皮苷合成路线

详细合成路线

橙皮苷上下游产品

橙皮苷上游产品

橙皮苷下游产品

橙皮苷制备

1.该品含于柠檬、柑桔、代代花等果皮中。在柑桔属（Cirtus）中，中果皮（白色海绵状组织）发达系统者多含柑桔甙，中果皮较薄系统者多含橙皮甙。本品系由干燥，成熟的橙皮中提取。将干橙皮粗碎，加3-6倍量水浸泡约0.5h，使之松软。再加入4-10%量的石灰及7-12倍量的水，搅拌均匀，检查pH值。要求pH值达11.5-12，否则应补加石灰或氢氧化钠。浸泡1.5-2h后，离心过滤，滤渣再加5-7倍量水并再用适量石灰调pH至11.5-12，继续浸泡后离心过滤。至滤液澄明后，加稀盐酸调pH至5，静置2d后，收集沉淀，用水洗至接近中性，即得粗品。将粗品用1%氢氧化钠及50%乙醇的混合溶游人部量溶解，过滤，滤液再用稀盐酸调pH至5，静置一夜，收集沉淀物，先用50%乙醇洗涤1次，再用水洗至接近中性，在70℃干燥，粉碎过筛，即得橙皮甙。对橙皮粉的总收率为0.6-1.8%。

2.橙皮粗粉加入水和适量石灰，搅拌均匀后以25%氢氧化钠调节PH
值在12～13，浸泡10～12H后压滤出液。弃去残渣，用浓盐酸调PH值至3～4，于70℃保温0.5H。冷却静置，沉淀完全后抽滤收集沉淀，水洗至中性，于80℃下干燥，此为橙皮素粗品。以甲醇为溶剂重结晶可得纯净橙皮素。

橙皮苷文献

Bio-refinery of orange peels waste: a new concept based on integrated green and solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin.

Ultrason. Sonochem. 24 , 72-9, (2015)

In this study, extraction of essential oil, polyphenols and pectin from orange peel has been optimized using microwave and ultrasound technology without adding any solvent but only "in situ" water whi...

Effects of pectinase clarification treatment on phenolic compounds of pummelo (Citrus grandis l. Osbeck) fruit juice.

J. Food Sci. Technol. 52 , 5057-65, (2015)

The purpose of this study is to investigate the changes occured on phenolic compounds between two Malaysian varieties of pummelo fruit juice: Ledang (PO55) and Tambun (PO52) post-enzymatic clarificati...

Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.

Food Chem. Toxicol. 74 , 51-9, (2014)

D-galactose, a reducing sugar, induces oxidative stress resulting in alteration in mitochondrial dynamics and apoptosis of neurons. Curcumin and hesperidin are antioxidants possessing multimodal funct...

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橙皮苷