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芹菜脑

芹菜脑用途

Apiole 是一种诱导凋亡 (apoptosis) 的抗肿瘤剂,诱导 G0/G1 细胞周期停滞而抑制人结肠癌细胞。Apiole 还在小鼠体内异种移植模型中显著抑制结肠肿瘤的发展。

芹菜脑名称

[ CAS 号 ]:
523-80-8

[ 中文名 ]:
洋芹脑

[ 英文名 ]:
Apiole (parsley)

[中文别名 ]:

[英文别名 ]:

Apiole (parsley)
Apiol
1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene
Petersiliencampher
3,6-dimethoxy-4,5-methylenedioxy-allylbenzene
1-allyl-3,4-methylenedioxy-2,5-dimethoxybenzene
Apiole
Apioline
5-Allyl-4,7-dimethoxy-1,3-benzodioxole
Parsley apiol

芹菜脑生物活性

[ 描述 ]:

Apiole 是一种诱导凋亡 (apoptosis) 的抗肿瘤剂,诱导 G0/G1 细胞周期停滞而抑制人结肠癌细胞。Apiole 还在小鼠体内异种移植模型中显著抑制结肠肿瘤的发展。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188.

[2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

芹菜脑物理化学性质

[ 密度 ]:
1.151g/cm3

[ 沸点 ]:
294ºC

[ 熔点 ]:
29ºC

[ 分子式 ]:
C₁₂H₁₄O₄

[ 分子量 ]:
222.24

[ 闪点 ]:
117.2ºC

[ 精确质量 ]:
222.08900

[ PSA ]:
36.92000

[ LogP ]:
2.16100

[ 折射率 ]:
1.53

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

芹菜脑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY2500000

CHEMICAL NAME :: Benzene, 1-allyl-2,5-dimethoxy-3,4-(methylenedioxy)-

CAS REGISTRY NUMBER :: 523-80-8

BEILSTEIN REFERENCE NO. :: 0195747

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H14-O4

MOLECULAR WEIGHT :: 222.26

WISWESSER LINE NOTATION :: T56 BO DO CHJ FO1 H2U1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1515 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

芹菜脑安全信息

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 海关编码 ]:
2932999099

芹菜脑合成路线

详细合成路线

芹菜脑海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

芹菜脑