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萎锈灵

萎锈灵用途

Carboxin (Carboxine) 是一种内吸杀菌剂和种子保护剂。

萎锈灵名称

[ CAS 号 ]:
5234-68-4

[ 中文名 ]:
萎锈灵

[ 英文名 ]:
Carboxin

[中文别名 ]:

莠锈灵

[英文别名 ]:

CARBOXIN
Vitavax 735D
2,3-dihydro-6-methyl-5-phenylcarbamyl-1,4-oxathiin
Vitavax 100
Carbathiine
MFCD00055403
EINECS 226-031-1
Carbathiin
5,6-Dihydro-2-methyl-1,4-oxathiine-3-carboxanilide
Vitavax 75W

萎锈灵生物活性

[ 描述 ]:

Carboxin (Carboxine) 是一种内吸杀菌剂和种子保护剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[体外研究]

Carboxin(Carboxine)是来自oxathiin类药剂的内吸性杀真菌剂。 Carboxin对真菌类Basideomycetes,Deuteromycetes和Phycomycetes具有高度特异性[1]。全身性杀菌剂Carboxin是线粒体中琥珀酸氧化的强效抑制剂[2]。

[参考文献]

[1]. Frampton CS, et al. Two polymorphic forms of the oxathiin systemic fungicide active carboxine. Acta Crystallogr E Crystallogr Commun. 2018 Nov 9;74(Pt 12):1741-1745.

[2]. G.A.White, et al. Oxathiin carboxamides highly active against carboxin-resistant succinic dehydrogenase complexes from carboxin-selected mutants of Ustilago maydis and Aspergillus nidulans. Pestic Biochem Physiol. 1978 Oct;9(2):165-182.

[相关活性小分子]

萎锈灵物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
420.6±45.0 °C at 760 mmHg

[ 熔点 ]:
91.1-91.7°C

[ 分子式 ]:
C₁₂H₁₃NO₂S

[ 分子量 ]:
235.302

[ 闪点 ]:
208.2±28.7 °C

[ 精确质量 ]:
235.066696

[ PSA ]:
63.63000

[ LogP ]:
3.00

[ 外观性状 ]:
灰白色晶体无气味的

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.636

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
10.095 g/100 mL

萎锈灵MSDS

萎锈灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP4550000

CHEMICAL NAME :: 1,4-Oxathiin-3-carboxamide, 5,6-dihydro-2-methyl-N-phenyl-

CAS REGISTRY NUMBER :: 5234-68-4

BEILSTEIN REFERENCE NO. :: 0983249

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C12-H13-N-O2-S

MOLECULAR WEIGHT :: 235.32

WISWESSER LINE NOTATION :: T6O DS BUTJ B1 CVMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 24 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 42200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54300 ug/m3/4H/6W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 161 gm/kg/2Y-I

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - fatty liver degeneration Blood - changes in erythrocyte (RBC) count

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 382 mg/kg/48H (Continuous)

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,235,1988 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

萎锈灵安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi,Xn

[ 风险声明 (欧洲) ]:
R21/22

[ 安全声明 (欧洲) ]:
36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RP4550000

[ 海关编码 ]:
2934999038

萎锈灵合成路线

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萎锈灵下游产品

萎锈灵制备

由乙酰乙酰苯胺与硫酰氯反应得到α-氯代乙酰乙酰苯胺，再与巯基乙醇缩合而得。原料消耗定额：乙酰乙酰苯胺1090kg/t、硫酰氯880kg/t、巯基乙醇（>95%）490kg/t、对甲苯磺酸30kg/t。

萎锈灵海关

[ 海关编码 ]: 2934999038

[ 中文概述 ]:
2934999038 萎锈灵,氧化萎锈灵。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2934999038 2-methyl-n-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide 4,4-dioxide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

萎锈灵文献

The Adh1 gene of the fungus Metarhizium anisopliae is expressed during insect colonization and required for full virulence.

Microbiol. Res. 172 , 57-67, (2015)

Zymography of alcohol dehydrogenase (ADH) activity in the entomopathogenic fungus Metarhizium anisopliae grown under various conditions revealed that micro-aerobic growth was associated with increased...

Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds.

Appl. Microbiol. Biotechnol. 70(6) , 735-9, (2006)

The antioxidative stress-response system is essential to fungi for tolerating exposure to phenolic compounds. We show how this system can be targeted to improve fungal control by using compounds that ...

Phototransformation of carboxin in water. Toxicity of the pesticide and its sulfoxide to aquatic organisms.

J. Agric. Food Chem. 52(20) , 6228-32, (2004)

Sunlight exposure of aqueous suspensions of carboxin (1) causes its phototransformation to sulfoxide 2 and minor components. Similar effects are observed in the presence of humic acid or nitrate or at...

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萎锈灵