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母菊薁

母菊薁用途

查马苏烯是一种天然化合物,是白三烯B4形成的抗氧化型抑制剂[1]。

母菊薁名称

[ CAS 号 ]:
529-05-5

[ 中文名 ]:
母菊薁

[ 英文名 ]:
Chamazulene

[中文别名 ]:

[英文别名 ]:

7-Ethyl-1,4-dimethylazulene
Azulene, 7-ethyl-1,4-dimethyl-
Chamazulene
7-Ethyl-1,4-dimethylazulene Chamazulen Dimethulene

母菊薁生物活性

[ 描述 ]:

查马苏烯是一种天然化合物,是白三烯B4形成的抗氧化型抑制剂[1]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 白三烯受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. H Safayhi, et al. Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Med. 1994 Oct;60(5):410-3.

[2]. Andrea Capuzzo, et al. Antioxidant and radical scavenging activities of chamazulene. Nat Prod Res. 2014;28(24):2321-3.

[3]. Ding Ma, et al. Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβpathway in in-vitro and in-vivo models. Biosci Biotechnol Biochem. 2020 Feb;84(2):402-410.

母菊薁物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
299.1±20.0 °C at 760 mmHg

[ 熔点 ]:
<25℃

[ 分子式 ]:
C₁₄H₁₆

[ 分子量 ]:
184.277

[ 闪点 ]:
137.4±12.5 °C

[ 精确质量 ]:
184.125198

[ LogP ]:
5.36

[ 外观性状 ]:
蓝色油状物

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
2-8°C

母菊薁MSDS

母菊薁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CO4780000

CHEMICAL NAME :: Azulene, 1,4-dimethyl-7-ethyl-

CAS REGISTRY NUMBER :: 529-05-5

BEILSTEIN REFERENCE NO. :: 1306577

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H16

MOLECULAR WEIGHT :: 184.30

WISWESSER LINE NOTATION :: L57J B1 F1 I2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RRESA8 Rastitel'nye Resursy. Plant Resources. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 3,67,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: RRESA8 Rastitel'nye Resursy. Plant Resources. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 3,67,1967

母菊薁安全信息

[ 危害声明 ]:
H413

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2902909090

母菊薁合成路线

母菊薁上下游产品

母菊薁上游产品

母菊薁下游产品

母菊薁制备

1. 由甘菊、苦艾等植物中得到。

母菊薁海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

母菊薁文献

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation.

Planta Med. 60(5) , 410-3, (1994)

Matricine and its transformation product chamazulene are constituents of chamomile extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since preparations from chamomile ...

[Pharmacologic studies on chamomile compounds. VI. Studies on the antiphlogistic effect of chamazulene and matricine].

Planta Med. 49(2) , 67-73, (1983)

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母菊薁