氯霉素棕榈酸酯

氯霉素棕榈酸酯用途

Chloramphenicol palmitate 是一种具有口服活性广谱抗生素 (antibiotic),对革兰氏阳性菌和革兰氏阴性菌有广泛的活性。Chloramphenicol palmitate 通过阻断肽基转移酶的合成来抑制细菌的蛋白质合成。Chloramphenicol palmitate 可作为含有氯霉素耐药基因的转化细胞的细菌筛选试剂 (bacterial selection agent)。

氯霉素棕榈酸酯名称

[ CAS 号 ]:
530-43-8

[ 中文名 ]:
氯霉素棕榈酸酯

[ 英文名 ]:
Chloramphenicol palmitate

[中文别名 ]:

棕榈酸氯霉素酯

[英文别名 ]:

Chlorambon
detreopal
CHLORAMPHENICOLPALMITATE,BP
cap-palmitate
Chloramphenicol palmitate
Clorolifarina
chloromycetinpalmitate
CHLORAMPHENICAL PALMITATE
EINECS 208-477-9
MFCD00083597

氯霉素棕榈酸酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Siti Nani Nurbaeti, et al. Sustained-release Microparticle Dry Powders of Chloramphenicol Palmitate or Thiamphenicol Palmitate Prodrugs for Lung Delivery as Aerosols.Eur J Pharm Sci. 2019 Oct 1;138:105028.

氯霉素棕榈酸酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
691.6±55.0 °C at 760 mmHg

[ 熔点 ]:
90ºC

[ 分子式 ]:
C₂₇H₄₂Cl₂N₂O₆

[ 分子量 ]:
561.538

[ 闪点 ]:
372.1±31.5 °C

[ 精确质量 ]:
560.242004

[ PSA ]:
121.45000

[ LogP ]:
9.04

[ 外观性状 ]:
晶体,溶于水

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.526

[ 储存条件 ]:
库房低温通风干燥

氯霉素棕榈酸酯MSDS

详细MSDS(安全技术说明书)

氯霉素棕榈酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT4735000

CHEMICAL NAME :: Palmitic acid, alpha-ester with D-threo-(-)-2,2-dichloro-N-(beta-hydroxy-alpha- (hydroxymethyl)-p-nitrophenethyl)acetamide

CAS REGISTRY NUMBER :: 530-43-8

BEILSTEIN REFERENCE NO. :: 2826438

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H42-Cl2-N2-O6

MOLECULAR WEIGHT :: 561.61

WISWESSER LINE NOTATION :: WNR DYQY1OV15&MVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,248,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: VHAGAS Verhandlungen der Anatomischen Gesellschaft. (VEB Gustav Fischer Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.) V.1- 1887- Volume(issue)/page/year: 71,623,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2340 No. of Facilities: 79 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 318 (estimated) No. of Female Employees: 132 (estimated)

氯霉素棕榈酸酯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
36/37-36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RT4735000

[ 海关编码 ]:
29414000

氯霉素棕榈酸酯合成路线

详细合成路线

氯霉素棕榈酸酯上下游产品

氯霉素棕榈酸酯上游产品

氯霉素棕榈酸酯下游产品

氯霉素棕榈酸酯制备

【方法一】
将α-甲基吡啶及苯加入反应锅，搅拌下加入氯霉素，保持32-37℃，滴加棕榈酰氯。加毕，继续搅拌4h，加至15倍水中，析出粗品。粗品经洗涤、脱色、重结晶，即得无味氯霉素。

氯霉素棕榈酸酯海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氯霉素棕榈酸酯文献

Structural, electronic, thermodynamical and charge transfer properties of Chloramphenicol Palmitate using vibrational spectroscopy and DFT calculations.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 101 , 335-42, (2013)

The global problem of advancing bacterial resistance to newer drugs has led to renewed interest in the use of Chloramphenicol Palmitate (C27H42Cl2N2O6) [Palmitic acid alpha ester with D-threo-(-),2-di...

Metabolism of some drugs by intestinal lactobacilli and their toxicological considerations.

Acta Pharmacol. Toxicol. (Copenh.) 58(1) , 11-5, (1986)

The bacterial metabolism of three drugs (sulphasalazine, phthalylsulphathiazole and chloramphenicol palmitate) and two dyes (tartrazine and methyl red) has been studied using a resting culture techniq...

The effect of exocrine pancreatic function on chloramphenicol pharmacokinetics in patients with cystic fibrosis.

Pediatr. Res. 23(4) , 388-92, (1988)

The effect of exocrine pancreatic function on the pharmacokinetics of the choramphenicol oral capsule (CAP-base), chloramphenicol palmitate oral liquid (CAP-P), and chloramphenicol succinate intraveno...

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