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棕榈酸

棕榈酸用途

Palmitic acid是一种常见于动物和植物中的长链饱和脂肪酸。

棕榈酸名称

[ CAS 号 ]:
57-10-3

[ 中文名 ]:
棕榈酸

[ 英文名 ]:
Palmitic acid

[中文别名 ]:

[英文别名 ]:

n-hexadecanoic acid
1-hexadecanoic acid
hexdecanoic acid
Hexadecanoic acid
MFCD00002747
EINECS 200-312-9
Neo-Fat 16
Palmitic acid

棕榈酸生物活性

[ 描述 ]:

Palmitic acid是一种常见于动物和植物中的长链饱和脂肪酸。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

[相关活性小分子]

棕榈酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
340.6±5.0 °C at 760 mmHg

[ 熔点 ]:
61-62.5 °C(lit.)

[ 分子式 ]:
C₁₆H₃₂O₂

[ 分子量 ]:
256.424

[ 闪点 ]:
154.1±12.5 °C

[ 精确质量 ]:
256.240234

[ PSA ]:
37.30000

[ LogP ]:
7.15

[ 外观性状 ]:
白色芯片,晶体或粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.454

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.

[ 水溶解性 ]:
insoluble

棕榈酸MSDS

棕榈酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT4550000

CHEMICAL NAME :: Palmitic acid

CAS REGISTRY NUMBER :: 57-10-3

BEILSTEIN REFERENCE NO. :: 0607489

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C16-H32-O2

MOLECULAR WEIGHT :: 256.48

WISWESSER LINE NOTATION :: QV15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 37,251,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,105,1966 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81460 No. of Facilities: 1477 (estimated) No. of Industries: 23 No. of Occupations: 34 No. of Employees: 20670 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81460 No. of Facilities: 5543 (estimated) No. of Industries: 55 No. of Occupations: 61 No. of Employees: 105420 (estimated) No. of Female Employees: 20470 (estimated)

棕榈酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
RT4550000

[ 海关编码 ]:
2915709000

棕榈酸合成路线

棕榈酸上下游产品

棕榈酸上游产品

棕榈酸下游产品

棕榈酸制备

1.自然界中广泛存在，几乎所有的油脂中都有含量不等的软脂酸组分。我国特产的乌桕油中，软脂酸的含量可高达60%以上，而棕榈树果实的棕榈油中含量大约为40%，但菜油中的含量则不足2%。将乌桕油或棕榈油水解、分馏、压榨分离不饱和脂肪酸后，经重结晶即制得棕榈酸。市售品棕榈酸一般熔点为57.5-62.5℃。

2.用板油或棕榈油经水解、酸化，分离不饱和脂肪酸后得棕榈酸，然后经重结晶可得纯棕榈酸。

3.将米糠油、椰子油、棕榈仁油等的混合脂肪酸经真空分馏而制得。

4. 烟草：OR，44；FC，9， 15， 18， 41， 43， 50；OR，18， 26；BU，9， 18， 26。

棕榈酸海关

[ 海关编码 ]: 2915709000

[ 中文概述 ]:
2915709000. 棕榈酸及其盐和酯、硬脂酸盐、酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 硬脂酸和软脂酸的含量

[ Summary ]:
2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

棕榈酸文献

Kinetics and utilization of lipid sources during acute exercise and acipimox.

Am. J. Physiol. Endocrinol. Metab. 307(2) , E199-208, (2014)

Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics a...

Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells.

J. Virol. 88(16) , 9233-44, (2014)

Diacylglycerol acyltransferase-1 (DGAT1) is involved in the assembly of hepatitis C virus (HCV) by facilitating the trafficking of the HCV core protein to the lipid droplet. Here, we abrogated DGAT1 e...

The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.

PLoS Genet. 11(3) , e1005027, (2015)

Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that com...

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棕榈酸