4β-羟基醉茄内酯E

4β-羟基醉茄内酯E用途

4β-羟基withanolide E,从秘鲁酸浆中分离,通过调节有丝分裂克隆扩增抑制3T3-L1细胞的脂肪细胞分化。4β-羟基withanolide E是一种脂肪生成抑制剂,抑制PPARγ、C/EBPα和脂肪细胞特异性分子aP2 mRNA的表达[1]。

4β-羟基醉茄内酯E名称

[ CAS 号 ]:
54334-04-2

[ 中文名 ]:
4β-羟基醉茄内酯E

[ 英文名 ]:
4β-Hydroxywithanolide E

4β-羟基醉茄内酯E生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> PPAR

研究领域 >> 代谢疾病

[参考文献]

[1]. Momochika Kumagai, et al. 4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. J Nat Med. 2021 Jan;75(1):232-239.

4β-羟基醉茄内酯E物理化学性质

[ 密度 ]:
1.39g/cm3

[ 沸点 ]:
728.3ºC at 760mmHg

[ 分子式 ]:
C₂₈H₃₈O₈

[ 分子量 ]:
502.59700

[ 闪点 ]:
242.1ºC

[ 精确质量 ]:
502.25700

[ PSA ]:
136.82000

[ LogP ]:
1.72520

[ 外观性状 ]:
粉末

[ 储存条件 ]:
室温

4β-羟基醉茄内酯E毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE7283000

CHEMICAL NAME :: Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, delta-lactone, (4-beta,5-beta,6-beta,17-alpha,22R)-

CAS REGISTRY NUMBER :: 54334-04-2

LAST UPDATED :: 198605

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H38-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31050 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986