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4,4',4''-三氨基三苯甲烷

4,4',4''-三氨基三苯甲烷用途

Tris(4-aminophenyl)methane 是一种三苯甲烷类染料。Tris(4-aminophenyl)methane 是一种稍弱的 HCV 解旋酶 (HCV helicase) 抑制剂。

4,4',4''-三氨基三苯甲烷名称

[ CAS 号 ]:
548-61-8

[ 中文名 ]:
4,4’,4"-三氨基三苯甲烷

[ 英文名 ]:
Tris(4-aminophenyl)methane

[中文别名 ]:

[英文别名 ]:

EINECS 208-952-0
4-[bis(4-aminophenyl)methyl]aniline
Tris(4-aminophenyl)methane

4,4',4''-三氨基三苯甲烷生物活性

[ 描述 ]:

Tris(4-aminophenyl)methane 是一种三苯甲烷类染料。Tris(4-aminophenyl)methane 是一种稍弱的 HCV 解旋酶 (HCV helicase) 抑制剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HCV

染料试剂

研究领域 >> 感染

[ 靶点 ]

HCV helicase[1]

[体外研究]

三(4-氨基苯基)甲烷(化合物8)显示出弱的HCV解旋酶抑制(在100μM时抑制30％)[1]。为了保留生物样品中的RNA用于分析,将样品与能够在水溶液中沉淀RNA的RNA防腐剂一起温育,所述水溶液例如三苯甲烷染料(例如,甲基绿,结晶紫,副玫瑰苯胺或三(氨基苯基))。甲烷),甲酚紫或钴离子。 RNA保存可用于免疫染色测定和其他组织化学方法[2]。

[参考文献]

[1]. Chen CS, et al. Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virushelicase. J Med Chem. 2009 May 14;52(9):2716-23.

[相关活性小分子]

4,4',4''-三氨基三苯甲烷物理化学性质

[ 密度 ]:
1.208g/cm3

[ 沸点 ]:
540.9ºC at 760mmHg

[ 分子式 ]:
C₁₉H₁₉N₃

[ 分子量 ]:
289.37400

[ 闪点 ]:
316.7ºC

[ 精确质量 ]:
289.15800

[ PSA ]:
78.06000

[ LogP ]:
5.35700

[ 折射率 ]:
1.701

[ 储存条件 ]:
2-8°C

4,4',4''-三氨基三苯甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB7350000

CHEMICAL NAME :: Methane, tris(4-aminophenyl)-

CAS REGISTRY NUMBER :: 548-61-8

BEILSTEIN REFERENCE NO. :: 2811314

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H19-N3

MOLECULAR WEIGHT :: 289.41

WISWESSER LINE NOTATION :: ZR DYR DZ&R DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,485,1986 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 gm/kg/47W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors Skin and Appendages - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/90W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors Skin and Appendages - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 gm/kg/64W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6880 mg/kg/43W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 gm/kg/39W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976

4,4',4''-三氨基三苯甲烷安全信息

[ 危害码 (欧洲) ]:
T+

[ 危险品运输编码 ]:
2811.0

[ 海关编码 ]:
2921420090

4,4',4''-三氨基三苯甲烷合成路线

详细合成路线

4,4',4''-三氨基三苯甲烷上下游产品

4,4',4''-三氨基三苯甲烷上游产品

4,4',4''-三氨基三苯甲烷下游产品

4,4',4''-三氨基三苯甲烷制备

用氢氧化钠溶液、硫黄配制多硫化钠，用多硫化钠作还原剂，在乙醇介质中将对硝基甲苯氧化还原，生成对氨基苯甲醛。后者在盐酸存在下与苯胺缩合，生成三（4-氨基苯基）甲烷盐酸盐，经烧碱中和、蒸出苯胺，再经盐酸酸化、活性炭脱色、液碱中和、干燥、粉碎，得成品。合成反应式如下

4,4',4''-三氨基三苯甲烷海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%