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玫红酸

玫红酸用途

玫瑰酸是Nrf2及其下游靶标的激活剂。玫瑰酸可增加血管生成因子的水平,减少炎症(TNF-α和IL-1β)和凋亡标志物(CXCL10和CCL2)。玫瑰酸恢复胰腺细胞的功能,保护内皮细胞免受内质网应激[1]。

玫红酸名称

[ CAS 号 ]:
603-45-2

[ 中文名 ]:
玫红酸

[ 英文名 ]:
Aurin

[中文别名 ]:

[英文别名 ]:

Aurin No. 555
MFCD00001624
EINECS 210-041-8
Aurin
rosolic acid
Corallin Spirit Soluble
4,4'-Dihydroxyfuchsone
Aurine
Corallin
p-Rosolic acid

玫红酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2

研究领域 >> 代谢疾病

[参考文献]

[1]. Amin KN, et al. Effect of Rosolic acid on endothelial dysfunction under ER stress in pancreatic microenvironment. Free Radic Res. 2021 Jun;55(6):698-713.

玫红酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
543.0±50.0 °C at 760 mmHg

[ 熔点 ]:
ca. 308ºC (decomposes)

[ 分子式 ]:
C₁₉H₁₄O₃

[ 分子量 ]:
290.31

[ 闪点 ]:
296.2±26.6 °C

[ 精确质量 ]:
290.094299

[ PSA ]:
57.53000

[ LogP ]:
3.15

[ 外观性状 ]:
红色晶体或粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.691

[ 储存条件 ]:
Store at room temperature.

[ 水溶解性 ]:
Solubility Practically insoluble in water, benzene; freely soluble in ethanol

玫红酸MSDS

玫红酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2914501900

玫红酸合成路线

玫红酸上下游产品

玫红酸上游产品

玫红酸下游产品

玫红酸制备

三、生产方法简介

由苯酚、草酸、硫酸的混合物经加热制取。

玫红酸海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

玫红酸文献

Ligand polarizability contributes to tau fibril binding affinity.

Bioorg. Med. Chem. 19 , 5147-54, (2011)

Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggrega...

Screening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship.

Microbios 78(315) , 83-90, (1994)

The activity of 45 compounds against bloodstream forms of Trypanosoma cruzi was investigated. The aim was to consider new agents which might subsequently be assayed for chemoprophylaxis in donated blo...

Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.

J. Mol. Biol. 221(3) , 765-72, (1991)

The X-ray crystal structure of recombinant wild-type azurin from Pseudomonas aeruginosa was determined by difference Fourier techniques using phases derived from the structure of the mutant His35Leu. ...

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玫红酸