AP-18
AP-18用途
AP-18名称
[ CAS 号 ]:
55224-94-7
[ 英文名 ]:
AP-18
[英文别名 ]:
- N-Desmethylclozapine
- 4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime
- AP-18
AP-18生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
TRPA1:~3 μM (IC50)
[体外研究]
[体内研究]
[参考文献]
AP-18物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
348.4±34.0 °C at 760 mmHg
[ 分子式 ]:
C11H12ClNO
[ 分子量 ]:
209.672
[ 闪点 ]:
164.5±25.7 °C
[ 精确质量 ]:
209.060745
[ PSA ]:
32.59000
[ LogP ]:
3.72
[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C
[ 折射率 ]:
1.529
[ 储存条件 ]:
-20°C,密闭,干燥
AP-18安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
22
[ 危险品运输编码 ]:
NONH for all modes of transport
AP-18文献
PLoS ONE 7(10) , e46917, (2012)
Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiolo...
TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice.PLoS ONE 4 , e7596, (2009)
Nitric oxide (NO) can induce acute pain in humans and plays an important role in pain sensitization caused by inflammation and injury in animal models. There is evidence that NO acts both in the centr...
A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis.Arthritis Rheum. 63 , 819-29, (2011)
To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in inflammatory hyperalgesia mediated by tumor necrosis factor α(TNFα) and joint inflammation.Mechanical hyperalgesia w...
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐乾明
产品详情:AP-18
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥815.0/5mg
¥1249.0/10mg
¥2915.0/25mg
¥4973.0/25mg
联系人:李先生
产品详情:AP 18
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥1636.0/5mg
¥809.48/5mg
¥1234.8/10mg
¥2867.48/25mg
联系人:夏言
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相关化合物
[AP-18]化源网提供AP-18CAS号55224-94-7,AP-18MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询AP-18上化源网,专业又轻松。>>电脑版:AP-18
标题:【AP-18】AP-18 CAS号:55224-94-7【结构式 性质 活性】-化源网 地址:https://www.chemsrc.com/amp/cas/55224-94-7_754110.html