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盐酸三甲氧苯酰胺

盐酸三甲氧苯酰胺用途

Trimethobenzamide hydrochloride 是多巴胺 D₂ 受体阻断剂，可用作预防恶心和呕吐的止吐剂。

盐酸三甲氧苯酰胺名称

[ CAS 号 ]:
554-92-7

[ 中文名 ]:
盐酸三甲氧苯酰胺

[ 英文名 ]:
Trimethobenzamide hydrochloride

[中文别名 ]:

盐酸曲美苄胺

[英文别名 ]:

Ametik hydrochloride
Trimethobenzamide hydrochloride
Trimethobenzamide HCL
Ibikin
UNII-WDQ5P1SX7Q
EINECS 209-075-6
Tigan
Poligerim
Anaus
Nauseton

盐酸三甲氧苯酰胺生物活性

[ 描述 ]:

Trimethobenzamide hydrochloride 是多巴胺 D2 受体阻断剂,可用作预防恶心和呕吐的止吐剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 其他

[ 靶点 ]

D2 receptor[1]

[体外研究]

Trimethobenzamide是一种(非吩噻嗪)苯甲酰胺止吐剂,可中枢作用阻断D2受体,从而通过阻断呕吐中心的呕吐冲动来抑制髓质化学感受器触发区[1]。

[体内研究]

Trimethobenzamide的口服生物利用度为60％至100％。口服给药后约45分钟达到峰值;肌肉注射后约30分钟肌内(IM)给药[1]。

[参考文献]

[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.

[相关活性小分子]

盐酸三甲氧苯酰胺物理化学性质

[ 密度 ]:
1.131g/cm3

[ 沸点 ]:
506.9ºC at 760mmHg

[ 熔点 ]:
187.5-190°

[ 分子式 ]:
C₂₁H₂₉ClN₂O₅

[ 分子量 ]:
424.91800

[ 精确质量 ]:
424.17600

[ PSA ]:
69.26000

[ LogP ]:
3.77570

[ 储存条件 ]:
2-8°C

盐酸三甲氧苯酰胺MSDS

详细MSDS(安全技术说明书)

盐酸三甲氧苯酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV4550000

CHEMICAL NAME :: Benzamide, N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethox y-, hydrochloride

CAS REGISTRY NUMBER :: 554-92-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H28-N2-O5.Cl-H

MOLECULAR WEIGHT :: 424.97

WISWESSER LINE NOTATION :: 1OR BO1 CO1 EVM1R DO2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,350,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 126,270,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 564 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,350,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 174,350,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4629 No. of Facilities: 109 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 3651 (estimated) No. of Female Employees: 3453 (estimated)

盐酸三甲氧苯酰胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H334

[ 警示性声明 ]:
P261-P280-P284-P301 + P312 + P330-P304 + P340-P342 + P311

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ 海关编码 ]:
2924299090

盐酸三甲氧苯酰胺合成路线

详细合成路线

盐酸三甲氧苯酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%