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己烯雌酚

己烯雌酚用途

Diethylstilbestrol是非甾体雌性激素,可作用于更年期和绝经后的紊乱。

己烯雌酚名称

[ CAS 号 ]:
56-53-1

[ 中文名 ]:
己烯雌酚

[ 英文名 ]:
Diethylstilbestrol

[中文别名 ]:

乙基雌酚

[英文别名 ]:

Stilboesterol
trans-Diethyl Stilbestrol
Stil
Percutacrine Oestrogenique Iscovesco
Sibol
4,4'-Stilbenediol, α,α'-diethyl-, (E)-
stilboestrol
4,4'-hex-3-ene-3,4-diyldiphenol
cyrena
Synthestrin

己烯雌酚生物活性

[ 描述 ]:

Diethylstilbestrol是非甾体雌性激素,可作用于更年期和绝经后的紊乱。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 内分泌

[参考文献]

[1]. Troisi, R., et al., Medical conditions among adult offspring prenatally exposed to diethylstilbestrol. Epidemiology, 2013. 24(3): p. 430-8.

[2]. Kebir, O. and M.O. Krebs, Diethylstilbestrol and risk of psychiatric disorders: a critical review and new insights. World J Biol Psychiatry, 2012. 13(2): p. 84-95.

[相关活性小分子]

己烯雌酚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
407.1±25.0 °C at 760 mmHg

[ 熔点 ]:
170-172 °C(lit.)

[ 分子式 ]:
C₁₈H₂₀O₂

[ 分子量 ]:
268.350

[ 闪点 ]:
186.9±17.8 °C

[ 精确质量 ]:
268.146332

[ PSA ]:
40.46000

[ LogP ]:
5.93

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.603

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Isomerizes rapidly in Benzene, Chloroform, and Ether.Keep Shielded from light.

[ 水溶解性 ]:
PRACTICALLY INSOLUBLE

己烯雌酚MSDS

详细MSDS(安全技术说明书)

己烯雌酚安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H335-H350-H360-H410

[ 警示性声明 ]:
P201-P280-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R40;R45;R61;R36/37/38;R51/53

[ 安全声明 (欧洲) ]:
S53-S36/37/39-S45-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
WJ5600000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2942000000

己烯雌酚合成路线

详细合成路线

己烯雌酚上下游产品

己烯雌酚上游产品

己烯雌酚下游产品

己烯雌酚海关

[ 海关编码 ]: 2942000000

己烯雌酚文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.

Toxicol. Sci. 141(1) , 78-89, (2014)

In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to ...

Analysis of endocrine disrupters and related compounds in sediments and sewage sludge using on-line turbulent flow chromatography-liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1352 , 29-37, (2014)

A novel fully automated method based on dual column switching using turbulent flow chromatography followed by liquid chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) was applied for t...

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