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D-葡糖-6-磷酸

D-葡糖-6-磷酸用途

D-Glucose 6-Phosphate 称 6-磷酸葡萄糖,是葡萄糖经过磷酸化 (在第 6 号碳) 之后生成的分子。它是生物细胞中的常见分子,参与磷酸戊糖途径与糖酵解等生化途径。

D-葡糖-6-磷酸名称

[ CAS 号 ]:
56-73-5

[ 中文名 ]:
D-葡萄糖-6-磷酸

[ 英文名 ]:
D-Glucose 6-Phosphate

[中文别名 ]:

D-葡糖-6-磷酸

[英文别名 ]:

EINECS 200-286-9
MFCD00136040
d(+)-glucopyranose 6-phosphate

D-葡糖-6-磷酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

这种二价阴离子在细胞中非常常见,因为进入细胞的大部分葡萄糖将以这种方式被磷酸化。

[参考文献]

[1]. Olsen BB, et al. Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy. Mol Imaging Biol. 2018 Jul 9.

[相关活性小分子]

D-葡糖-6-磷酸物理化学性质

[ 密度 ]:
1.97g/cm3

[ 沸点 ]:
564.1ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₃O₉P

[ 分子量 ]:
260.13600

[ 闪点 ]:
295ºC

[ 精确质量 ]:
260.03000

[ PSA ]:
174.56000

[ 外观性状 ]:
无色液体

[ 折射率 ]:
1.637

[ 储存条件 ]:
−20°C

D-葡糖-6-磷酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ7160000

CHEMICAL NAME :: D-Glucose, 6-(dihydrogen phosphate)

CAS REGISTRY NUMBER :: 56-73-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H13-O9-P

MOLECULAR WEIGHT :: 260.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 10 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 81,105,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3153 No. of Facilities: 577 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 10643 (estimated) No. of Female Employees: 7844 (estimated)

D-葡糖-6-磷酸安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
34

[ 安全声明 (欧洲) ]:
S26;S27;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 1760 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
LZ7160000

[ 包装等级 ]:
III

D-葡糖-6-磷酸合成路线

详细合成路线

D-葡糖-6-磷酸文献

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

Org. Biomol. Chem. 10(48) , 9601-19, (2012)

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their abi...

Reduced cellular Mg__ content enhances hexose 6-phosphate dehydrogenase activity and expression in HepG2 and HL-60 cells.

Arch. Biochem. Biophys. 548 , 11-9, (2014)

We have reported that Mg(2+) dynamically regulates glucose 6-phosphate entry into the endoplasmic reticulum and its hydrolysis by the glucose 6-phosphatase in liver cells. In the present study, we rep...

Teaching NeuroImages: diagnostic utility of FDG-PET in neurolymphomatosis.

Neurology 81(1) , e3, (2013)

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