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3alpha,21-二羟基-5alpha-孕甾-20-酮

3alpha,21-二羟基-5alpha-孕甾-20-酮用途

3α,21-二羟基-5α-pregnan-20-one(THDOC)是一种内源性神经甾体,是GABAA受体的正调节因子。3α,21-二羟基-5α-pregnan-20-one可增强神经元对低浓度GABA在α4β1δGABAA受体的反应。

3alpha,21-二羟基-5alpha-孕甾-20-酮名称

[ CAS 号 ]:
567-02-2

[ 中文名 ]:
3alpha,21-二羟基-5alpha-孕甾-20-酮

[ 英文名 ]:
THDOC

[中文别名 ]:

21-羟基全孕烯醇酮

[英文别名 ]:

[3H]-Allotetrahydrodeoxycorticosterone
21-HYDROXYALLOPREGNANOLONE
TDOC
ALLOTETRADEOXYCORTICOSTERONE
ALLOTETRAHYDRO DOC
ALLOTETRAHYDRO SUBSTANCE 'Q'
ALLOTETRAHYDRODEOXYCORTICOSTERONE
ALLOTETRAHYDROCORTEXONE
ALLO TH DOC
5A-pregnane-3A,21-diol-20-one

3alpha,21-二羟基-5alpha-孕甾-20-酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

3alpha,21-二羟基-5alpha-孕甾-20-酮物理化学性质

[ 密度 ]:
1.115g/cm3

[ 沸点 ]:
470.3ºC at 760mmHg

[ 分子式 ]:
C₂₁H₃₄O₃

[ 分子量 ]:
334.49300

[ 闪点 ]:
252.3ºC

[ 精确质量 ]:
334.25100

[ PSA ]:
57.53000

[ LogP ]:
3.56760

[ 折射率 ]:
1.54

3alpha,21-二羟基-5alpha-孕甾-20-酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

3alpha,21-二羟基-5alpha-孕甾-20-酮上下游产品

3alpha,21-二羟基-5alpha-孕甾-20-酮上游产品

3alpha,21-二羟基-5alpha-孕甾-20-酮下游产品

3alpha,21-二羟基-5alpha-孕甾-20-酮文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 976-977 , 6-18, (2015)

Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as ste...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

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