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(R)-(+)-阿替洛尔

(R)-(+)-阿替洛尔用途

(R)-(+)-Atenolol 是活性较低的 (R,S)-atenolol 的对映体。(R,S)-atenolol 是 β-肾上腺素能受体拮抗剂。

(R)-(+)-阿替洛尔名称

[ CAS 号 ]:
56715-13-0

[ 中文名 ]:
(R)-(+)-阿替洛尔

[ 英文名 ]:
(R)-(+)-Atenolol

[英文别名 ]:

Prenormin
MFCD00074917

(R)-(+)-阿替洛尔生物活性

[ 描述 ]:

(R)-(+)-Atenolol 是活性较低的 (R,S)-atenolol 的对映体。(R,S)-atenolol 是 β-肾上腺素能受体拮抗剂。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Batra S, et al. Bioassay, determination and separation of enantiomers of atenolol by direct and indirect approaches using liquid chromatography: A review. Biomed Chromatogr. 2018 Jan;32(1).

[2]. Stoschitzky K, et al. Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies. Chirality. 1993;5(1):15-9.

(R)-(+)-阿替洛尔物理化学性质

[ 密度 ]:
1.125g/cm3

[ 沸点 ]:
508ºC at 760mmHg

[ 熔点 ]:
148-152ºC(lit.)

[ 分子式 ]:
C₁₄H₂₂N₂O₃

[ 分子量 ]:
266.33600

[ 闪点 ]:
261.1ºC

[ 精确质量 ]:
266.16300

[ PSA ]:
84.58000

[ LogP ]:
1.54330

[ 折射率 ]:
1.54

[ 储存条件 ]:
-20°C，密闭，干燥

(R)-(+)-阿替洛尔安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924299090

(R)-(+)-阿替洛尔上下游产品

(R)-(+)-阿替洛尔上游产品

(R)-(+)-阿替洛尔下游产品

(R)-(+)-阿替洛尔海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(R)-(+)-阿替洛尔文献

Effects of nebivolol on endothelial gene expression during oxidative stress in human umbilical vein endothelial cells.

Mediators Inflamm. 2008 , 367590, (2008)

The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare th...

Molecular Dynamics Simulation and NMR Investigation of the Association of the _-Blockers Atenolol and Propranolol with a Chiral Molecular Micelle.

Chem. Phys. 457 , 133-146, (2015)

Molecular dynamics simulations and NMR spectroscopy were used to compare the binding of two _-blocker drugs to the chiral molecular micelle poly-(sodium undecyl-(L)-leucine-valine). The molecular mice...

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