异丙胺

异丙胺用途

【用途一】
用于制农药、药物、硫化促进剂，也用作硬水处理剂、去垢剂等。无色透明液体，无机械杂质。主要用于农药、医药、染料和橡胶加工等。
【用途二】
用于生产农药、医药、染料中间体，橡胶促进剂，硬水处理剂及表面活性剂等
【用途三】
异丙胺即2-氨基丙烷(2-aminopropane)，在农药工业中有广泛应用，可用于合成有机磷杀虫剂甲基异柳磷、乙基异柳磷、苯线磷；昆虫生长调节剂噻嗪酮；杀菌剂异菌脲；除草剂灭草松、氟草净、莠去津、扑灭津、扑草净等，此外，异丙胺也是医药、染料、橡胶硫化促进剂、乳化剂、洗涤剂、水处理剂等的原料。
【用途四】
异丙胺为溶剂和有机合成原料。用以合成农药、医药、染料中间体、橡胶硫化促进剂、乳化剂、洗涤剂、去垢剂、脱毛剂、硬水处理剂、表面活性剂和纺织物助剂等，可用于生产农药巴丹和除草剂阿特拉津、莠灭净、扑灭净、杀草净等多种除草剂，医药上用于肝乐、茚酚盐酸盐、心得安盐酸盐、吲哚心安等药物。
【用途五】
溶剂。有机合成。乳化剂。

异丙胺名称

[ CAS 号 ]:
75-31-0

[ 中文名 ]:
异丙胺

[ 英文名 ]:
isopropylamine

[中文别名 ]:

[英文别名 ]:

Dimethylmethaneamine
1-Methylethylamine
2-Propanamine
Isopropylamine
2-Aminopropane
MFCD00008082
2-Amino-propaan
propan-2-amine
Propane, 2-amino-
isopropyl amine

异丙胺物理化学性质

[ 密度 ]:
0.7±0.1 g/cm3

[ 沸点 ]:
30.9±8.0 °C at 760 mmHg

[ 熔点 ]:
-101 °C

[ 分子式 ]:
C₃H₉N

[ 分子量 ]:
59.110

[ 闪点 ]:
-32.2±0.0 °C

[ 精确质量 ]:
59.073498

[ PSA ]:
26.02000

[ LogP ]:
0.21

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
2.04 (vs air)

[ 蒸汽压 ]:
607.7±0.1 mmHg at 25°C

[ 折射率 ]:
1.389

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride.

[ 水溶解性 ]:
soluble

异丙胺MSDS

详细MSDS(安全技术说明书)

异丙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NT8400000

CHEMICAL NAME :: Isopropylamine

CAS REGISTRY NUMBER :: 75-31-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 36

MOLECULAR FORMULA :: C3-H9-N

MOLECULAR WEIGHT :: 59.13

WISWESSER LINE NOTATION :: ZY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/15/1971

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/15/1971

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 Volume(issue)/page/year: 17JUN1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,238,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7000 ppm/40M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,7,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 Volume(issue)/page/year: 17JUN1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1800 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975 *** REVIEWS *** ACGIH TLV-STEL 24 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,141,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3) JAN 1993 OEL-BELGIUM:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-FRANCE:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (12 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 40990 No. of Facilities: 808 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 13196 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 40990 No. of Facilities: 235 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 8134 (estimated) No. of Female Employees: 3174 (estimated)

异丙胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H224-H301 + H311 + H331-H314-H335

[ 警示性声明 ]:
P210-P261-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R12;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S29

[ 危险品运输编码 ]:
UN 1221 3/PG 1

[ WGK德国 ]:
1

[ RTECS号 ]:
NT8400000

[ 包装等级 ]:
I

[ 危险类别 ]:
3

异丙胺合成路线

详细合成路线

异丙胺上下游产品

异丙胺上游产品

异丙胺下游产品

异丙胺制备

工业上生产异丙胺主要有以下两种方法：

1.丙酮氢化氨化法将原料丙酮送入以铜-镍-白土为催化剂的反应器中，在常压和150-220℃温度条件下，通入氢和氨进行反应，反应产物经精馏提纯得一异丙胺，同时也有二异丙胺生成。丙酮的转化率达98%，一、二异丙胺总产率达90%以上。原料消耗定额：丙酮1390kg/t、液氨450kg/t。

2.异丙醇氢化氨化法异丙醇与氨和氢气在195℃、1.72MPa下，通过氢氧化钡活化的多孔镍铝催化剂进行反应，生成一异丙胺和二异丙胺。反应总转化率可达86%，产品收率（以异丙醇计）达96%，其中含一异丙胺37%，二异丙胺33%，异丙醇12%，水18%。

精制方法：异丙胺是用溴代异丙烷与氨的醇溶液反应，或丙酮与氨和氢在镍-铜-白土的催化下反应制得的。因此可能含有丙酮、溴代异丙烷、异丙醇和其他各种丙基胺类等杂质。可用精馏法进行精制。要得到高纯度的异丙胺，可加入无水氧化钡放置数日，然后在钠存在下进行蒸馏，收集131.961Pa下31.4℃的馏分，进行再蒸馏。

异丙胺文献

Comparison of microwave, ultrasound and accelerated-assisted solvent extraction for recovery of polyphenols from Citrus sinensis peels.

Food Chem. 187 , 507-16, (2015)

Peel of Citrus sinensis contains significant amounts of bioactive polyphenols that could be used as ingredients for a number of value-added products with health benefits. Extraction of polyphenols fro...

Evolution of strategies to achieve baseline separation of ten anionic, water-soluble sulfated estrogens via achiral packed column supercritical fluid chromatography.

J. Chromatogr. A. 1370 , 240-5, (2014)

Near baseline separation of ten sulfated sodium salts of various structurally related estrogens employing a variety of bonded stationary phase packed columns was obtained using a conventional supercri...

Generic chiral method development in supercritical fluid chromatography and ultra-performance supercritical fluid chromatography.

J. Chromatogr. A. 1363 , 311-22, (2014)

The development of chiral separation methods in pharmaceutical industry is often a very tedious, labour intensive and expensive process. A trial-and-error approach remains frequently used, given the u...

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异丙胺