<生产厂家价格>

二马来酸乙酰奋乃静

二马来酸乙酰奋乃静用途

Acetophenazine dimaleate 是一种抗精神病试剂,对焦虑抑郁有效。

二马来酸乙酰奋乃静名称

[ CAS 号 ]:
5714-00-1

[ 中文名 ]:
二马来酸乙酰奋乃静

[ 英文名 ]:
ACETOPHENAZINE

[中文别名 ]:

[英文别名 ]:

sch6673
acetophenazinemaleate
Acetophazine maleate
ACETOPHENZAINEMALEATE
tindal
Acetophenazine dimaleate

二马来酸乙酰奋乃静生物活性

[ 描述 ]:

Acetophenazine dimaleate 是一种抗精神病试剂,对焦虑抑郁有效。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8.

二马来酸乙酰奋乃静物理化学性质

[ 沸点 ]:
608.7ºC at 760 mmHg

[ 熔点 ]:
167-168.5°

[ 分子式 ]:
C₂₇H₃₃N₃O₆S

[ 分子量 ]:
527.63200

[ 闪点 ]:
321.9ºC

[ 精确质量 ]:
527.20900

[ PSA ]:
146.92000

[ LogP ]:
3.14450

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

二马来酸乙酰奋乃静毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB4180000

CHEMICAL NAME :: Ketone, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenot hiazin-2-yl methyl, dimaleate

CAS REGISTRY NUMBER :: 5714-00-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C23-H29-N3-O2-S.2C4-H4-O4

MOLECULAR WEIGHT :: 643.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 14,250,1956 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 415 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01100

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974

二马来酸乙酰奋乃静安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
OB4180000

二马来酸乙酰奋乃静文献

[CLINICAL OBSERVATIONS ON THE ACTION OF TINDAL IN PSYCHIATRIC TREATMENT].

Neurol. Neurochir. Psychiatr. Pol. 14 , 683-6, (1964)

Synergism of combined lithium-neuroleptic therapy: a double-blind, placebo-controlled case study.

Am. J. Psychiatry 138(1) , 81-3, (1981)

The authors describe a longitudinal, placebo-controlled study of the response to drug treatment of a 62-year-old schizoaffective patient hospitalized for 40 years. While neither lithium nor a neurolep...

HEMODYNAMIC EFFECTS OF IMIPRAMINE, ACETOPHENAZINE, AND TRIFLUOPERAZINE IN GERIATRIC PSYCHIATRY.

Dis. Nerv. Syst. 26 , 427-9, (1965)

更多文献