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维生素K3

维生素K3用途

Menadione是合成的萘醌,可在体内转化为活性维生素K2。

维生素K3名称

[ CAS 号 ]:
58-27-5

[ 中文名 ]:
甲萘醌

[ 英文名 ]:
Menadione

[中文别名 ]:

[英文别名 ]:

Aquakay
Karcon
Kipca
Menadione
Synkay
Koaxin
Kaykot
Kanone
2-methyl-1,4-naphthalenedione
EINECS 200-372-6

维生素K3生物活性

[ 描述 ]:

Menadione是合成的萘醌,可在体内转化为活性维生素K2。

[ 相关类别 ]:

天然产物 >> 醌类

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. http://en.wikipedia.org/wiki/Menadione

[相关活性小分子]

维生素K3物理化学性质

[ 密度 ]:
1.225 g/cm3

[ 沸点 ]:
304.5ºC at 760 mmHg

[ 熔点 ]:
105-107 °C(lit.)

[ 分子式 ]:
C₁₁H₈O₂

[ 分子量 ]:
172.18000

[ 闪点 ]:
113.8ºC

[ 精确质量 ]:
172.05200

[ PSA ]:
34.14000

[ LogP ]:
2.01190

[ 外观性状 ]:
亮黄色晶体

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. May be light sensitive. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
INSOLUBLE

维生素K3MSDS

维生素K3毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL9100000

CHEMICAL NAME :: 1,4-Naphthoquinone, 2-methyl-

CAS REGISTRY NUMBER :: 58-27-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C11-H8-O2

MOLECULAR WEIGHT :: 172.19

WISWESSER LINE NOTATION :: L66 BV EVJ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Vascular - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10500 mg/kg/30D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 775 mg/kg/6D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in spleen Nutritional and Gross Metabolic - changes in iron

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1860 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 20 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 178,57,1987 *** REVIEWS *** TOXICOLOGY REVIEW JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 59,1,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84779 No. of Facilities: 63 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 1170 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84779 No. of Facilities: 771 (estimated) No. of Industries: 5 No. of Occupations: 16 No. of Employees: 6103 (estimated) No. of Female Employees: 2166 (estimated)

维生素K3安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R43

[ 安全声明 (欧洲) ]:
S26-S36-S37/39-S24

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL9100000

[ 海关编码 ]:
2914700090

维生素K3合成路线

维生素K3上下游产品

维生素K3上游产品

维生素K3下游产品

维生素K3制备

1.甲基萘用铬酐氧化而得。将2-甲基萘溶解于冰醋酸中，搅拌冷却到40℃以下，缓缓加入铬酐与等量水的混和液，使温度维持在35-40℃。加毕，在40℃保温0.5h，升温到70℃保温45min，再升温到85℃保温15min，将反应物倾入大量水中，不断搅拌下沉淀出2-甲萘醌。过滤，滤饼反复用水洗，至水溶液无酸味，滤干得2-甲萘醌。收率51%。2-甲基萘也可用重铬酸钠；重铬酸钾氧化收率大致相同。

2.由甲苯醌与丁二烯环合得到2-甲基萘氢醌，再经铬酸氧化而得。将甲苯醌加入冰醋酸中溶解，通入丁二烯，在20℃以下通至所需量。密闭静置20h后，加热使剩余的丁二烯逸出，继续加热至110℃左右回流3h，再减压蒸馏回收冰醋酸约30%。然后冷却至40℃以下，缓缓加入铬酸与等量水的混合液，使温度保持在65-70℃，加毕，在70-80保温1h而生成甲萘醌。

维生素K3海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

维生素K3文献

Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress.

Microvasc. Res. 98 , 16-22, (2015)

Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter invo...

Minimal detection of nuclear mutations in XP-V and normal cells treated with oxidative stress inducing agents.

J. Biochem. Mol. Toxicol. 28(12) , 568-77, (2014)

Elevated levels of reactive oxygen species (ROS) can be induced by exposure to various chemicals and radiation. One type of damage in DNA produced by ROS is modification of guanine to 7,8-dihydro-8-ox...

Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach.

Toxicology 306 , 24-34, (2013)

Oxidative stress plays an important role in chemically induced liver injury, however, our insight into molecular responses to different oxygen radicals is fragmentary. Since these cellular responses w...

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