3-甲氧基苯甲酰胺

3-甲氧基苯甲酰胺用途

3-Methoxybenzamide (3-MBA) 是 ADP-核糖转移酶 (ADPRTs) 和 PARP 的抑制剂,抑制枯草芽孢杆菌的细胞分裂,导致细胞最终裂解。3-Methoxybenzamide (3-MBA) 可促进蓝薯 (Solanum tuberosum L. subsp. andigenum) 植株的生长、微瘤化和转化效率。

3-甲氧基苯甲酰胺名称

[ CAS 号 ]:
5813-86-5

[ 中文名 ]:
3-甲氧基苯甲酰胺

[ 英文名 ]:
3-Methoxybenzamide

[中文别名 ]:

间茴香酰胺

[英文别名 ]:

3-Methoxybenzamide
MFCD00007986
3-Methoxy-benzoesaeure-amid
3-Methoxy-benzamid
3-methoxy-benzoic acid amide
m-anisamide
Benzamide, 3-methoxy-
Benzamide,3-methoxy
3-Methoxy-benzamide
EINECS 227-379-7

3-甲氧基苯甲酰胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 表观遗传学 >> PARP

信号通路 >> 细胞周期/DNA损伤 >> PARP

[体外研究]

在营养生长和孢子形成过程中,3-甲氧基苯甲酰胺(0-30mm)通过FtsZ系统影响隔膜[1]。3-甲氧基苯甲酰胺(3mb；0.2-0.6mm)显著促进离体繁殖植物的生长和微块茎的形成[2]。细胞活力测定[1]细胞系：ftsZ突变株。浓度：0-30mm。培养时间：30℃过夜。结果：直接或间接改变ftsZ结合或水解鸟嘌呤核苷酸的能力,最终抑制Zring的形成。

[参考文献]

[1]. Y Ohashi, et al. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis. J Bacteriol. 1999 Feb;181(4):1348-51.

[2]. Venkateswari J. Chetty, et al. Poly (ADP-ribose) polymerase inhibitor 3-methoxybenzamide enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum). In Vitro Cellular & Developmental Biology - Plant (2020).

3-甲氧基苯甲酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
280.0±23.0 °C at 760 mmHg

[ 熔点 ]:
132.5-135.5 °C(lit.)

[ 分子式 ]:
C₈H₉NO₂

[ 分子量 ]:
151.163

[ 闪点 ]:
146.8±18.9 °C

[ 精确质量 ]:
151.063324

[ PSA ]:
52.32000

[ LogP ]:
0.85

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
室温，干燥

3-甲氧基苯甲酰胺MSDS

3-甲氧基苯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5463333

CHEMICAL NAME :: Benzamide, 3-methoxy-

CAS REGISTRY NUMBER :: 5813-86-5

BEILSTEIN REFERENCE NO. :: 2206857

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 28,335,1994

3-甲氧基苯甲酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CV5463333

[ 海关编码 ]:
2924299090

3-甲氧基苯甲酰胺合成路线

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3-甲氧基苯甲酰胺上游产品

3-甲氧基苯甲酰胺下游产品

3-甲氧基苯甲酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-甲氧基苯甲酰胺文献

Characterization of the superinduction of the c-myc proto-oncogene in fibroblasts by benzamide derivatives.

Mol. Cell Biochem. 124(2) , 175-81, (1993)

In mouse fibroblasts stimulated from quiescence into proliferation by serum the induction of expression of the c-myc proto-oncogene is strongly stimulated by 3-methoxybenzamide. Similar superinduction...

Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor.

Int. J. Immunopharmacol. 17(4) , 265-71, (1995)

6(5H)-phenanthridinone, a recently identified poly(ADP-ribose)polymerase (PARP) inhibitor, is able, at micromolar concentrations, to inhibit concanavalin A-induced lymphocyte proliferation and to pote...

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

Bioorg. Med. Chem. Lett. 19 , 524-7, (2009)

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identificat...

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