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盐酸丙美卡因

盐酸丙美卡因用途

Proparacaine盐酸盐是电压门控钠离子通道拮抗剂,ED50为3.4 mM。

盐酸丙美卡因名称

[ CAS 号 ]:
5875-06-9

[ 中文名 ]:
盐酸丙美卡因

[ 英文名 ]:
Proparacaine Hydrochloride

[中文别名 ]:

[英文别名 ]:

EINECS 227-541-7
Proxymetacaine Hydrochloride
Proxymetacaine Hcl
PROPARACAINE HCL
Proparacaine hydrochloride
MFCD00083467
ak-taine

盐酸丙美卡因生物活性

[ 描述 ]:

Proparacaine盐酸盐是电压门控钠离子通道拮抗剂,ED50为3.4 mM。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 神经疾病

天然产物 >> 其他

[参考文献]

[1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78.

[2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1:

[3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94.

[4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53.

[相关活性小分子]

盐酸丙美卡因物理化学性质

[ 沸点 ]:
434.4ºC at 760mmHg

[ 分子式 ]:
C₁₆H₂₇ClN₂O₃

[ 分子量 ]:
330.850

[ 闪点 ]:
216.5ºC

[ 精确质量 ]:
330.171021

[ PSA ]:
64.79000

[ LogP ]:
3.93940

[ 储存条件 ]:
-20°C

盐酸丙美卡因MSDS

详细MSDS(安全技术说明书)

盐酸丙美卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3065000

CHEMICAL NAME :: Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 5875-06-9

LAST UPDATED :: 199504

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H26-N2-O3.Cl-H

MOLECULAR WEIGHT :: 330.90

WISWESSER LINE NOTATION :: 3OR BZ DVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3371 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3223 No. of Facilities: 412 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3442 (estimated) No. of Female Employees: 2127 (estimated)

盐酸丙美卡因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H317-H319-H332

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R36;R43

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG3065000

盐酸丙美卡因文献

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