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(S)-萝卜丁酚

(S)-萝卜丁酚用途

Sulforaphene 可从萝卜籽中提取得到,对绒毛叶种子的ED50 值为2 x 10-4 M。Sulforaphene 促进癌细胞的凋亡,通过下调EGFR、p-ERK1/2 和 NF‐κB 等抑制癌细胞迁移。

(S)-萝卜丁酚名称

[ CAS 号 ]:
592-95-0

[ 中文名 ]:
莱菔素

[ 英文名 ]:
(1E)-4-Isothiocyanato-1-(methylsulfinyl)-1-butene

[中文别名 ]:

[英文别名 ]:

4-isothiocyanato-1-(methylsulfinyl)-1-buten
S-SULFORAPHENE
(1E)-4-Isothiocyanato-1-(methylsulfinyl)-1-butene
SULFORAPHENE,L
4-methylsulfinyl-3-butenyl isothiocyanate
RAPHANIN
L-SULFORAPHENE
L-SULPHORAPHENE
SULFORAPHANE,DL-(SH)
sativin

(S)-萝卜丁酚生物活性

[ 描述 ]:

Sulforaphene 可从萝卜籽中提取得到,对绒毛叶种子的ED50 值为2 x 10-4 M。Sulforaphene 促进癌细胞的凋亡,通过下调EGFR、p-ERK1/2 和 NF‐κB 等抑制癌细胞迁移。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> JAK/STAT信号通路 >> EGFR

信号通路 >> 蛋白酪氨酸激酶 >> EGFR

信号通路 >> MAPK/ERK信号通路 >> ERK

信号通路 >> 干细胞及 Wnt 通路 >> ERK

[参考文献]

[1]. Kuang P, et al. Separation and purification of sulforaphene from radish seeds using macroporous resin and preparative high-performance liquid chromatography. Food Chem. 2013 Jan 15;136(2):342-7.

[2]. Anita M. Brinker, et al. Herbicidal activity of sulforaphene from stock (Matthiola incana). Journal of Chemical Ecology. Vol. 19. No. 10, 1993.

[3]. Mondal A, et al. Sulforaphene promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. General Physiology and Biophysics, 27 Nov 2015, 35(1):25-34.

[4]. Ren K, et al. Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway. J Biochem Mol Toxicol. 2017 Aug;31(8).

(S)-萝卜丁酚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
362.2±42.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₉NOS₂

[ 分子量 ]:
175.272

[ 闪点 ]:
172.8±27.9 °C

[ 精确质量 ]:
175.012558

[ PSA ]:
80.73000

[ LogP ]:
0.47

[ 外观性状 ]:
略淡黄色液体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.567

[ 储存条件 ]:
-20°C，密闭，干燥

(S)-萝卜丁酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX8944000

CHEMICAL NAME :: Isothiocyanic acid, 4-(methylsulfinyl)-3-butenyl ester

CAS REGISTRY NUMBER :: 592-95-0

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O-S2

MOLECULAR WEIGHT :: 175.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),357,1982

(S)-萝卜丁酚

(S)-萝卜丁酚用途

(S)-萝卜丁酚名称

(S)-萝卜丁酚生物活性

(S)-萝卜丁酚物理化学性质

(S)-萝卜丁酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

(S)-萝卜丁酚合成路线

详细合成路线

(S)-萝卜丁酚上下游产品

(S)-萝卜丁酚上游产品

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