巯基乙醇

巯基乙醇用途

【用途一】
用于合成染料、农药、医药等，在橡胶、纺织、塑料、涂料工业中可用作助剂
【用途二】
用作增塑剂及杀虫剂，也用于染料的制造
【用途三】
作为有机合成中间体，用于农药、医药、染料、照相化学品的生产。在橡胶、纺织、塑料、涂料工业中亦可用作助剂。聚合级高纯巯基乙醇可用作氯乙烯、丙烯腈等的调取剂，以及聚合催化剂、聚合物交联剂、固化剂。该品得到美国食品药物管理局的批准，可用作丙烯腈、苯乙烯、甲基丙烯酸甲酯三元树脂制食品包装用吹塑容器时的添加剂。

巯基乙醇名称

[ CAS 号 ]:
60-24-2

[ 中文名 ]:
2-巯基乙醇

[ 英文名 ]:
mercaptoethanol

[中文别名 ]:

巯基乙醇

[英文别名 ]:

emery5791
2-ME
mercaptoethanol
2-hydroxyethane-1-thiol
mercaptoethyl alcohol
2-Sulfanylethanol
2-sulfhydryl-ethanol
Bis-Mercaptoethanol
usafek-4196
β-Hydroxyethylmercaptan

巯基乙醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
157.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-100 °C

[ 分子式 ]:
C₂H₆OS

[ 分子量 ]:
78.133

[ 闪点 ]:
73.9±0.0 °C

[ 精确质量 ]:
78.013931

[ PSA ]:
59.03000

[ LogP ]:
-0.23

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
2.69 (vs air)

[ 蒸汽压 ]:
1.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.479

[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品分开储运

[ 水溶解性 ]:
soluble

[ 凝固点 ]:
<100℃

巯基乙醇MSDS

详细MSDS(安全技术说明书)

巯基乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL5600000

CHEMICAL NAME :: Ethanol, 2-mercapto-

CAS REGISTRY NUMBER :: 60-24-2

BEILSTEIN REFERENCE NO. :: 0773648

LAST UPDATED :: 199710

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C2-H6-O-S

MOLECULAR WEIGHT :: 78.14

WISWESSER LINE NOTATION :: SH2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13200 mg/m3

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3220 mg/kg/4W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 30 mmol/L

REFERENCE :: BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 425,1,1976 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84674 No. of Facilities: 133 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1437 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84674 No. of Facilities: 1497 (estimated) No. of Industries: 5 No. of Occupations: 13 No. of Employees: 14140 (estimated) No. of Female Employees: 4607 (estimated)

巯基乙醇安全信息

[ 符号 ]:

GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331-H310-H315-H317-H318-H373-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P302 + P350-P305 + P351 + P338

[ 靶器官 ]:
Heart, Liver

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R22;R24;R36/37/38;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61-S29-S23

[ 危险品运输编码 ]:
UN 2966 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
KL5600000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2930909090

巯基乙醇合成路线

详细合成路线

巯基乙醇上下游产品

巯基乙醇上游产品

巯基乙醇下游产品

巯基乙醇制备

1.早期采用氯乙醇与硫氢化钠反应制得。环氧乙烷与硫化氢按摩尔比1：3.5配合，以强碱性阴离子交换树脂为催化剂，在42℃左右反应。所得粗品含量约52%，还含少量硫二甘醇（沸点282℃），较易分离获得2-巯基乙醇。

2. 23克钠溶于400毫升精馏酒精，通入硫化氢使饱和(6小时)。在1小时内同时通入44克环氧乙烷和硫化氢于混合物中，此过程中温度保持低于30℃。放置过夜后，将反应混合物倾入水中，加60毫升冰麟酸以中和溶液，用乙醚萃取。乙醚萃取液用无水硫酸钠干干燥，蒸去溶剂，将残余物进行蒸馏，得24克沸点 58℃/12mm馏份，经鉴定为β一巯基乙醇。还得到29克沸点147℃/6mm馏份，为硫代二甘醇。

3. 在1升三颈瓶中，将240克结品硫化钠在水浴上熔化，通硫化氢使饱和。加入150克乙醇再通硫化氢以饱和之。保持低于20℃，慢慢加入120克氯乙醇，将反应混合物在室温放置36小时。通氯化氢直到混合物呈酸性。滤去氯化钠。滤液经减压分馏，得β一巯基乙醇，产率26一30%。
残余物再分馏可得硫代二甘醇。

巯基乙醇海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

巯基乙醇文献

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

Biochem. J. 467(2) , 345-52, (2015)

Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Wh...

Effect of (2)H and (18)O water isotopes in kinesin-1 gliding assay.

PeerJ 2 , e284, (2014)

We show for the first time the effects of heavy-hydrogen water ((2)H2O) and heavy-oxygen water (H2 (18)O) on the gliding speed of microtubules on kinesin-1 coated surfaces. Increased fractions of isot...

Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.

Mol. Pharm. 11(7) , 1991-6, (2014)

Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. H...

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