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β-萘黄酮

β-萘黄酮用途

β-萘酚黄酮是一种非致癌的AhR激动剂,作为诱导AhR转录活性的阳性对照物[1]。β-萘酚黄酮抑制过氧化氢诱导的细胞凋亡[2]。

β-萘黄酮名称

[ CAS 号 ]:
6051-87-2

[ 中文名 ]:
β-萘黄酮

[ 英文名 ]:
β-Naphthoflavone

[中文别名 ]:

[英文别名 ]:

3-phenylbenzo[f]chromen-1-one
1H-Naphtho[2,1-b]pyran-1-one, 3-phenyl-
MFCD00064288
EINECS 227-958-4
b-Naphthoflavone
BIDD:ER0570
3-Phenyl-1H-benzo[f]chromen-1-one
β-Naphthoflavone
5,6-Benzoflavone
b-NF

β-萘黄酮生物活性

[ 描述 ]:

β-萘酚黄酮是一种非致癌的AhR激动剂,作为诱导AhR转录活性的阳性对照物[1]。β-萘酚黄酮抑制过氧化氢诱导的细胞凋亡[2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 芳基烃受体

研究领域 >> 神经疾病

[参考文献]

[1]. Ishida T, Takechi S. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44(10):711-720.

[2]. Zhu Y, et al. α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med. 2017 Mar;13(3):1143-1150.

β-萘黄酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
460.9±45.0 °C at 760 mmHg

[ 熔点 ]:
185-189 °C

[ 分子式 ]:
C₁₉H₁₂O₂

[ 分子量 ]:
272.30

[ 闪点 ]:
215.8±22.3 °C

[ 精确质量 ]:
272.083740

[ PSA ]:
30.21000

[ LogP ]:
4.79

[ 外观性状 ]:
yellow to tan

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
2-8°C

β-萘黄酮MSDS

β-萘黄酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL6200000

CHEMICAL NAME :: 1H-Naphtho(2,1-b)pyran-1-one, 3-phenyl-

CAS REGISTRY NUMBER :: 6051-87-2

BEILSTEIN REFERENCE NO. :: 0018991

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H12-O2

MOLECULAR WEIGHT :: 272.31

WISWESSER LINE NOTATION :: T B666 CV FOJ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03239 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg/3D-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 11,580,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 600 mg/kg/4D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 15,93,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 120 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 24,1,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,159,1987

β-萘黄酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi,C,F

[ 风险声明 (欧洲) ]:
22-34-11

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL6200000

[ 海关编码 ]:
2914399090

β-萘黄酮合成路线

β-萘黄酮上下游产品

β-萘黄酮上游产品

β-萘黄酮下游产品

β-萘黄酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

β-萘黄酮文献

Physiological response of alligator gar juveniles (Atractosteus spatula) exposed to sub-lethal doses of pollutants.

Fish Physiol. Biochem. 41 , 1015-27, (2015)

Alligator gar populations have declined because of overfishing, habitat loss and pollution. Over time, the exposure to different pollutants have affected these fishes as a consequence of their high tr...

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium.

EMBO J. 34 , 1319-35, (2015)

Snail family members regulate epithelial-to-mesenchymal transition (EMT) during invasion of intestinal tumours, but their role in normal intestinal homeostasis is unknown. Studies in breast and skin e...

Direct surface visualization of biofilms with high spin coordination clusters using Magnetic Resonance Imaging.

Acta Biomater. 31 , 167-77, (2016)

Magnetic Resonance Imaging is a powerful tool for the investigation of a biofilms' physical structure determining mass transport behavior which is of major importance in biofilm research. The entire b...

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