<生产厂家价格>

丁苯酞

丁苯酞用途

Butylphthalide(3-n-Butylphthalide)是抗脑缺血药物,最初从芹菜种中分离出,对中风动物模型显示有效。

丁苯酞名称

[ CAS 号 ]:
6066-49-5

[ 中文名 ]:
3-丁基-1(3H)-异苯并呋喃酮

[ 英文名 ]:
3-n-Butylphthalide

[中文别名 ]:

[英文别名 ]:

3-Butyl-phthalide
1(3H)-Isobenzofuranone, 3-butyl-
3-Butyl-2-benzofuran-1(3H)-one
UNII:822Q956KGM
Butylphthalide
3-n-butylphthalide
3-Butylphthalide
EINECS 228-000-8

丁苯酞生物活性

[ 描述 ]:

Butylphthalide(3-n-Butylphthalide)是抗脑缺血药物,最初从芹菜种中分离出,对中风动物模型显示有效。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 2013;126(18):3405-10.

[2]. Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26.

[3]. Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12(31):5995-6004.

[4]. Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33.

[相关活性小分子]

丁苯酞物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
312.8±31.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂H₁₄O₂

[ 分子量 ]:
190.238

[ 闪点 ]:
128.3±22.2 °C

[ 精确质量 ]:
190.099380

[ PSA ]:
26.30000

[ LogP ]:
3.08

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
库房通风低温干燥

丁苯酞毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3692000

CHEMICAL NAME :: Phthalide, 3-butyl-

CAS REGISTRY NUMBER :: 6066-49-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H14-O2

MOLECULAR WEIGHT :: 190.26

WISWESSER LINE NOTATION :: T56 BVO DHJ D4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,251,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,251,1979

丁苯酞安全信息

[ 海关编码 ]:
2932209090

丁苯酞海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

丁苯酞