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替考拉宁

替考拉宁用途

Teicoplanin是一种半合成的糖肽抗生素, 预防和治疗革兰氏阳性菌引起的严重感染, 包括耐Methicillin的金黄色葡萄球菌和肠球菌。

替考拉宁名称

[ CAS 号 ]:
61036-62-2

[ 中文名 ]:
替考拉宁

[ 英文名 ]:
Teicoplanin

[英文别名 ]:

teichomycin
TEICOPLANIN
TEICOPLANIN,JP
Tagocid
TeicoplaninSodium
8327a
TEIC
Teicoplanin(sterile,non-sterile)
antibiotic8327a
Teocoplanin

替考拉宁生物活性

[ 描述 ]:

Teicoplanin是一种半合成的糖肽抗生素, 预防和治疗革兰氏阳性菌引起的严重感染, 包括耐Methicillin的金黄色葡萄球菌和肠球菌。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

替考拉宁物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 分子式 ]:
C₁₃₀H₁₇₅Cl₂N₉O₃₇R₆

[ 分子量 ]:
2526.73

[ PSA ]:
662.41000

[ LogP ]:
0.40

[ 折射率 ]:
1.754

[ 储存条件 ]:
2-8℃

替考拉宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WY1559000

CHEMICAL NAME :: Teicoplanin

CAS REGISTRY NUMBER :: 61036-62-2

LAST UPDATED :: 198910

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 14 mg/kg/31D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,613,1986

替考拉宁安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
WY1559000

替考拉宁文献

Role of extra-cellular fatty acids in vancomycin induced biofilm formation by vancomycin resistant Staphylococcus aureus.

Pak. J. Pharm. Sci. 26(2) , 383-9, (2013)

In the present study a vancomycin resistant Staphylococcus aureus (S. aureus) (VRSA) (Labeled as CP2) was isolated from the blood of a post-operative cardiac patient is described. It harbors a plasmid...

A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.

Sci. Transl. Med. 7 , 290ra89, (2015)

Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing...

Once-weekly dalbavancin versus daily conventional therapy for skin infection.

N. Engl. J. Med. 370(23) , 2169-79, (2014)

Dalbavancin, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. DISCOVER 1 and DISCOVER 2 were identicall...

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