顺式-4-羟基-L-脯氨酸

顺式-4-羟基-L-脯氨酸用途

cis-4-Hydroxy-L-proline,一种脯氨酸类似物,是胶原蛋白产生的抑制剂。cis-4-Hydroxy-L-proline 可通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。cis-4-Hydroxy-L-proline 还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。

顺式-4-羟基-L-脯氨酸名称

[ CAS 号 ]:
618-27-9

[ 中文名 ]:
顺式-4-羟基-L-脯氨酸

[ 英文名 ]:
cis-4-hydroxy-L-proline

[中文别名 ]:

[英文别名 ]:

D-Proline, 4-hydroxy-, (4R)-
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
cis-4-Hydroxy-L-proline
(4R)-4-Hydroxy-D-proline
cis-4-Hydroxyproline
MFCD00064319
(4S)-4-Hydroxy-L-prolin
cis-4-Hydroxy-D-proline
EINECS 210-542-1

顺式-4-羟基-L-脯氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 代谢疾病

[参考文献]

[1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.

[2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.

[3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.

[4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

顺式-4-羟基-L-脯氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
355.2±42.0 °C at 760 mmHg

[ 熔点 ]:
257ºC

[ 分子式 ]:
C₅H₉NO₃

[ 分子量 ]:
131.130

[ 闪点 ]:
168.6±27.9 °C

[ 精确质量 ]:
131.058243

[ PSA ]:
69.56000

[ LogP ]:
-1.84

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
水溶性：可溶

顺式-4-羟基-L-脯氨酸MSDS

顺式-4-羟基-L-脯氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

顺式-4-羟基-L-脯氨酸合成路线

顺式-4-羟基-L-脯氨酸上下游产品

顺式-4-羟基-L-脯氨酸上游产品

顺式-4-羟基-L-脯氨酸下游产品

顺式-4-羟基-L-脯氨酸制备

将明胶、骨胶、干酪素、大豆表皮蛋白质等用盐酸水解，再用亚硝化法提取亚氨酸后经树脂层析后精制、结晶而成。

顺式-4-羟基-L-脯氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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