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双氢麦角胺甲磺酸盐

双氢麦角胺甲磺酸盐用途

Dihydroergotamine甲磺酸盐为麦角生物碱,可作用于偏头疼。

双氢麦角胺甲磺酸盐名称

[ CAS 号 ]:
6190-39-2

[ 中文名 ]:
甲磺酸二氢麦角胺

[ 英文名 ]:
Dihydro Ergotamine Mesylate

[中文别名 ]:

[英文别名 ]:

Ikaran
EINECS 228-235-6
dihydroergotamine methane sulfonate salt
dihydroergotamine methanesulfonate
dolo[4,3-fg]quinoléine-9-carboxamide (1:1)
Agit
Ergont
DET MS
MFCD00058615
dhe45

双氢麦角胺甲磺酸盐生物活性

[ 描述 ]:

Dihydroergotamine甲磺酸盐为麦角生物碱,可作用于偏头疼。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[参考文献]

[1]. Colman, I., et al., Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature. Ann Emerg Med, 2005. 45(4): p. 393-401.

[2]. Saper, J.R., et al., DHE in the pharmacotherapy of migraine: potential for a larger role. Headache, 2006. 46 Suppl 4: p. S212-20.

[3]. Schaerlinger, B., et al., Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J Pharmacol, 2003. 140(2): p. 277-84.

[相关活性小分子]

双氢麦角胺甲磺酸盐物理化学性质

[ 沸点 ]:
1001.8ºC at 760 mmHg

[ 熔点 ]:
232°C

[ 分子式 ]:
C₃₄H₄₁N₅O₈S

[ 分子量 ]:
679.783

[ 闪点 ]:
559.7ºC

[ 精确质量 ]:
679.267578

[ PSA ]:
180.96000

[ LogP ]:
2.87050

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
-20 ° (C=0.25, JP Method)

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
methanol: 21 mg/mL

双氢麦角胺甲磺酸盐MSDS

详细MSDS(安全技术说明书)

双氢麦角胺甲磺酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE7920000

CHEMICAL NAME :: Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt)

CAS REGISTRY NUMBER :: 6190-39-2

LAST UPDATED :: 199509

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C33-H37-N5-O5.C-H4-O3-S

MOLECULAR WEIGHT :: 679.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,468,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,468,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982

双氢麦角胺甲磺酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
1544

[ WGK德国 ]:
3

[ RTECS号 ]:
KE7920000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

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双氢麦角胺甲磺酸盐文献

Role of 5-HT1B/1Dreceptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats

Life Sci. 92(22) , 1046-54, (2013)

Aims The present study analyzed the potential antinociceptive effect of the antimigraine drugs sumatriptan, dihydroergotamine or methysergide in rats submitted to the formalin test. Moreover, by using...

Structural basis for molecular recognition at serotonin receptors.

Science 340(6132) , 610-4, (2013)

Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the human 5-HT1B G protein-coupled receptor ...

Intrapulmonary and intravenous administrations of dihydroergotamine mesylate have similar cardiovascular effects in the conscious dog.

Br. J. Pharmacol. 154(6) , 1254-65, (2008)

The effects of intrapulmonary artery (i.p.a.) administration of dihydroergotamine mesylate (DHE) were evaluated.Conscious beagle dogs (n=4) were given DHE via the i.p.a. or i.v. route as two 0.014 mg ...

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