硫辛酸

硫辛酸用途

>98%,Standard References

硫辛酸作用

B族维生素
用于治疗急性及慢性肝炎、肝硬化、肝性昏迷、脂肪肝、糖尿病等。
抗氧化剂
被称为“万能抗氧化剂”，更是自由基捕手，是机体细胞利用糖类等能源物质产生能量所需的一种限制性必需营养物质，广泛用于治疗和预防心脏病、糖尿病等多种疾病。一般认为它能保存和再生其它抗氧化剂，如维生素C和E等，并能平衡血糖浓度。有效增强体内免疫系统，免受于自由基的破坏。
它对多种病症具有治疗功效：肝病、糖尿病、人类后天免疫不全带原者、艾滋病、牛皮藓、湿疹、烧伤、皮肤癌、多发性硬化症、帕金森氏症、神经科方面的疾病、风湿病、风湿性关节炎、红斑性狼疮、硬皮症、自体免疫方面的疾病、白内障、其它眼科疾病、心脏病、中风、动脉硬化、用于急性及慢性肝炎、肝硬变、肝性昏迷、脂肪肝等疾病。
一种重金属螯合剂
2HLa+ M2+（二价金属） ====2H+ + [M(La)4]-，介电常数很高
可抑制早老性痴呆
将硫辛酸类药物这种价格低廉的糖尿病辅助治疗药物与治疗阿尔茨海默症的常用药物乙酰胆碱酯酶抑制剂配合使用，可以有效抑制病人病情发作，并使部分病人的病情得到缓解。
作用力很强
它参与能量代谢，增加其它抗氧化剂消灭自由基的能力，促进恢复，提高人体增肌减脂的能力，还可以提高胰岛素敏感性，帮助肌酸导入肌肉细胞，硫辛酸是挡住衰老的七种营养品之一。可以美颜、活化细胞、改善生发。

硫辛酸名称

[ CAS 号 ]:
62-46-4

[ 中文名 ]:
硫辛酸

[ 英文名 ]:
(+)-Thioctic acid

[中文别名 ]:

[英文别名 ]:

1,2-Dithiolane-3-pentanoic acid, (3R)-
α-Lipoic acid
5-[3-(1,2-Dithiolanyl)]pentanoic Acid
a-Liponic acid
Thioctic acid
MFCD01631142
d-[3-(1,2-Dithiacyclopentyl)]pentanoic Acid
Lipoicin
EINECS 200-534-6
δ-[3-(1,2-dithiacyclopentyl)]pentanoic acid

硫辛酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
362.5±11.0 °C at 760 mmHg

[ 熔点 ]:
48-52 °C(lit.)

[ 分子式 ]:
C₈H₁₄O₂S₂

[ 分子量 ]:
206.326

[ 闪点 ]:
173.0±19.3 °C

[ 精确质量 ]:
206.043518

[ PSA ]:
87.90000

[ LogP ]:
2.16

[ 外观性状 ]:
浅黄色粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
室温

硫辛酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1190000

CHEMICAL NAME :: 1,2-Dithiolane-3-valeric acid

CAS REGISTRY NUMBER :: 62-46-4

BEILSTEIN REFERENCE NO. :: 0122410

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H14-O2-S2

MOLECULAR WEIGHT :: 206.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 502 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 41,79,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 197 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 60,278,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 480 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9998 No. of Facilities: 138 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 429 (estimated) No. of Female Employees: 141 (estimated)

硫辛酸安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S24/25

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

硫辛酸上下游产品

硫辛酸上游产品

硫辛酸下游产品

硫辛酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

硫辛酸