硫辛酸钠

硫辛酸钠用途

α-硫辛酸钠(硫代辛酸钠；(±)-α-硫辛酸钠；DL-α-硫辛酸钠)是一种抗氧化剂。α-硫辛酸钠抑制NF-κB依赖的HIV-1 LTR激活。α-硫辛酸钠诱导肝癌细胞内质网应激介导的凋亡。α-硫辛酸钠可用于研究糖尿病、神经病变、肥胖、异常妊娠等疾病[1][2][3][4][5]。

硫辛酸钠名称

[ CAS 号 ]:
2319-84-8

[ 中文名 ]:
硫辛酸钠

[ 英文名 ]:
Sodium thioctate

[英文别名 ]:

Epakon
Sodium thioctate
Tioctene
Eparidasi
Thioctan
Tioctan
Tioicorzan
Tioctinessa
6,8-Thioctic acid sodium salt
Thioctic acid sodium salt

硫辛酸钠生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 抗感染 >> HIV

研究领域 >> 内分泌

研究领域 >> 感染

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[ 靶点 ]

NF-κB

HIV

Human Endogenous Metabolite

Microbial Metabolite

[参考文献]

[1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65.

[2]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.

[3]. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217.

[4]. Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139.

[5]. Salehi B, et al. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019 Aug 9;9(8):356.

硫辛酸钠物理化学性质

[ 沸点 ]:
362.5ºC at 760mmHg

[ 熔点 ]:
241-253 °C

[ 分子式 ]:
C₈H₁₃NaO₂S₂

[ 分子量 ]:
228.30700

[ 闪点 ]:
173ºC

[ 精确质量 ]:
228.02500

[ PSA ]:
90.73000

[ LogP ]:
1.45040

[ 蒸汽压 ]:
3.07E-06mmHg at 25°C

[ 储存条件 ]:
室温

硫辛酸钠MSDS

详细MSDS(安全技术说明书)

硫辛酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1185700

CHEMICAL NAME :: 1,2-Dithiolane-3-valeric acid, sodium salt

CAS REGISTRY NUMBER :: 2319-84-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H13-O2-S2.Na

MOLECULAR WEIGHT :: 228.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1138,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 197 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1138,1969

硫辛酸钠安全信息

[ 海关编码 ]:
2934999090

硫辛酸钠海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%