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富马酸二乙酯

富马酸二乙酯用途

Diethyl fumarate 是一种内源性代谢产物。

富马酸二乙酯名称

[ CAS 号 ]:
623-91-6

[ 中文名 ]:
富马酸二乙酯

[ 英文名 ]:
Diethyl fumarate

[中文别名 ]:

[英文别名 ]:

2-Butenedioic acid(2E)-, 1,4-diethyl ester
2-Butenedioic acid, diethyl ester, (2E)-
Diethyl-(2E)-but-2-endioat
EINECS 210-819-7
Diethyl (2E)-but-2-enedioate
Diethyl (2E)-2-butenedioate
Fumaric acid, diethyl ester (8CI)
Diethyl fumarate
MFCD00064455
Diethyl maleate

富马酸二乙酯生物活性

[ 描述 ]:

Diethyl fumarate 是一种内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

富马酸二乙酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
214.0±0.0 °C at 760 mmHg

[ 熔点 ]:
41641ºC

[ 分子式 ]:
C₈H₁₂O₄

[ 分子量 ]:
172.178

[ 闪点 ]:
93.3±0.0 °C

[ 精确质量 ]:
172.073563

[ PSA ]:
52.60000

[ LogP ]:
1.68

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.443

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acids, bases, reducing agents.

[ 水溶解性 ]:
immiscible

富马酸二乙酯MSDS

富马酸二乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM5950000

CHEMICAL NAME :: 2-Butenedioic acid, diethyl ester, (E)-

CAS REGISTRY NUMBER :: 623-91-6

BEILSTEIN REFERENCE NO. :: 0775347

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H12-O4

MOLECULAR WEIGHT :: 172.20

WISWESSER LINE NOTATION :: 2OV1U1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81805 No. of Facilities: 367 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 1350 (estimated)

富马酸二乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S23

[ 危险品运输编码 ]:
NA 1993 / PGIII

[ WGK德国 ]:
3

[ RTECS号 ]:
EM5950000

[ 海关编码 ]:
29171990

富马酸二乙酯合成路线

富马酸二乙酯上下游产品

富马酸二乙酯上游产品

富马酸二乙酯下游产品

富马酸二乙酯制备

1.由反丁烯二酸与乙醇在硫酸催化下酯化而得。

2.制法：

于装有搅拌器、分水器的反应瓶中，加入富马酸（2）290g（2.5mol）无水乙醇370g（8mol），浓硫酸40g，苯1000mL，共沸脱水。苯层流回反应瓶，水层分出，反应约12h。将反应物倒入大量的水中，分出苯层。有机层水洗，再用饱和碳酸钠溶液洗涤，水洗，无水硫酸钠干燥。蒸出苯后，减压蒸馏，收集96～99℃/1.33kPa的馏分，得富马酸二乙酯（1）300g，收率70%。

富马酸二乙酯海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

富马酸二乙酯文献

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.

PLoS ONE 9(6) , e98385, (2014)

Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic...

Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst.

J. Biomater. Sci. Polym. Ed. 13(1) , 95-108, (2002)

Diethyl fumarate and propylene glycol were reacted in the presence of a zinc chloride catalyst to synthesize poly(propylene fumarate) (PPF) over a period of 12 hours. The kinetics of the transesterifi...

Facile preparation of the tosylhydrazone derivatives of a series of racemic trans-3,4-substituted cyclopentanones.

Molecules 17(1) , 1-14, (2011)

We report the synthesis and characterization of a variety of trans-3,4-substituted cyclopentanones and the corresponding tosylhydrazone derivatives starting with diethyl fumarate. Protection of the ke...

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