β-氰基-L-丙氨酸

β-氰基-L-丙氨酸用途

β-cyano-L-Alanine (Beta-cyano-l-alanine),一种在高等植物中广泛存在的腈,由氰基丙氨酸合成酶从氰化物和半胱氨酸作为底物酶促产生。 β-cyano-L-Alanine 消除了乙醇对脑缺血/再灌注 (I/R) 损伤的保护作用。

β-氰基-L-丙氨酸名称

[ CAS 号 ]:
6232-19-5

[ 中文名 ]:
β-氰基-L-丙氨酸

[ 英文名 ]:
3-cyano-L-alanine

[英文别名 ]:

AmbotzHAA5740
3-cyano-L-alanine
b-Cyano-L-Alanine
Propanoic acid, 2-amino-3-cyano-, (2S)-
(2S)-2-Amino-3-cyanopropanoic acid
L-3-Cyanoalanine
β-Cyano-L-alanine
(S)-2-amino-3-cyanopropanoic acid
L-Alanine,3-cyano

β-氰基-L-丙氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

β-氰基-L-丙氨酸(腹腔注射,50 mg/kg)可消除乙醇对脑缺血/再灌注(I/R)损伤的保护作用。动物模型：成年(出生后60天)雄性C57BL/6J小鼠(25-30g)灌胃给予乙醇[2]剂量：50mg/kg给药：腹腔注射结果：取消乙醇对脑I/R损伤的保护作用。

[参考文献]

[1]. Piotrowski M, et al. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase.J Med Chem. J Biol Chem. 2001 Jan 26;276(4):2616-21.

[2]. McCarter KD, et al. Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine γ-lyase. Alcohol. 2019 May;76:81-89.

β-氰基-L-丙氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
368.1±32.0 °C at 760 mmHg

[ 分子式 ]:
C₄H₆N₂O₂

[ 分子量 ]:
114.103

[ 闪点 ]:
176.4±25.1 °C

[ 精确质量 ]:
114.042931

[ PSA ]:
87.11000

[ LogP ]:
-0.72

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.502

[ 储存条件 ]:
-20°C

β-氰基-L-丙氨酸MSDS

β-氰基-L-丙氨酸安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2926909090

β-氰基-L-丙氨酸合成路线

β-氰基-L-丙氨酸上下游产品

β-氰基-L-丙氨酸上游产品

β-氰基-L-丙氨酸下游产品

β-氰基-L-丙氨酸海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

β-氰基-L-丙氨酸文献

Evolution of heteromeric nitrilase complexes in Poaceae with new functions in nitrile metabolism.

Proc. Natl. Acad. Sci. U. S. A. 104(47) , 18848-53, (2007)

Members of the nitrilase 4 (NIT4) family of higher plants catalyze the conversion of beta-cyanoalanine to aspartic acid and asparagine, a key step in cyanide detoxification. Grasses (Poaceae) possess ...

Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat.

J. Agric. Food Chem. 49(10) , 5075-80, (2001)

When young rats were fed a diet containing common vetch seed for 1 month, they excreted in the urine approximately 7 times more thiocyanate than they had ingested. Vicianin, prunasin, and beta-cyanoal...

Maize nitrilases have a dual role in auxin homeostasis and beta-cyanoalanine hydrolysis.

J. Exp. Bot. 58(15-16) , 4225-33, (2007)

The auxin indole-3-acetic acid (IAA), which is essential for plant growth and development, is suggested to be synthesized via several redundant pathways. In maize (Zea mays), the nitrilase ZmNIT2 is e...

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