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1,6-己二醇

1,6-己二醇用途

【用途一】
用于农药除虫菊酯、有机过氧化物、环状麝香、聚乙烯塑料交联剂和聚醚橡胶的生产
【用途二】
用于生产聚氨酯、不饱和聚酯、增塑剂、胶凝剂的硬化剂、润滑油的热稳妥定性改良剂等。

1,6-己二醇名称

[ CAS 号 ]:
629-11-8

[ 中文名 ]:
1,6-己二醇

[ 英文名 ]:
Hexan-1,6-diol

[中文别名 ]:

[英文别名 ]:

1,6-Hexylene Glycol
6-hydroxy-1-hexanol
EINECS 211-074-0
1,6-Hexanediol solution
1,6-dihydroxyhexane
1,6-hexandiol
Hexamethylenediol
Hexamethylene glycol
1,6-hexadiol
1,6-Hexanediol

1,6-己二醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
239.7±8.0 °C at 760 mmHg

[ 熔点 ]:
40-43ºC

[ 分子式 ]:
C₆H₁₄O₂

[ 分子量 ]:
118.174

[ 闪点 ]:
101.7±0.0 °C

[ 精确质量 ]:
118.099380

[ PSA ]:
40.46000

[ LogP ]:
-0.07

[ 外观性状 ]:
无色晶体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.450

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 0.1 g/mL, clear, colorless | 500 g/L

1,6-己二醇MSDS

1,6-己二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO2100000

CHEMICAL NAME :: 1,6-Hexanediol

CAS REGISTRY NUMBER :: 629-11-8

BEILSTEIN REFERENCE NO. :: 1633461

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H14-O2

MOLECULAR WEIGHT :: 118.20

WISWESSER LINE NOTATION :: Q6Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,210,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,210,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3730 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1738 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 49,385,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83598 No. of Facilities: 36 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 1740 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83598 No. of Facilities: 59 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 3529 (estimated) No. of Female Employees: 313 (estimated)

1,6-己二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S23-S24/25-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
MO2100000

[ 海关编码 ]:
2905399090

1,6-己二醇合成路线

1,6-己二醇上下游产品

1,6-己二醇上游产品

1,6-己二醇下游产品

1,6-己二醇制备

1.由己二酸二乙酯或已二酸二甲酯在金属钠、乙醇或在铅铬氧化物的存在下进行催化还原，或将2,4二炔-1,6-二醇催化还原而制得。例如由乙二酸二乙酯加氢还原。上述反应催化剂为亚铬酸铜，通氢压力为3.79-20.68MPa，反应温度为255℃，所得产品收率为85%-90%。

2.将原料己二酸二乙酯和催化剂亚铬酸铜先加到高压釜中，闭紧后，再通入合格氢气，控制压力为 3.79～20.68MPa。然后搅拌并加热至255℃进行反应，直到氢被吸收完全：

停止搅拌并冷却至常压过滤，滤出的催化剂用乙醇洗涤数次，将洗涤液并入滤液。加入40%氢氧化钠溶液，加热回流2h，之后，蒸出乙醇，蒸气温度达95℃时停止蒸馏，冷却后，用乙醚充分萃取，依次蒸出乙醚、水和乙醇，最后减压蒸馏，在533Pa 下收集143～144℃馏分，即为成品。

3.制法：

于高压反应釜中，加入己二酸二乙酯(2)101g(0.52mol),10gCu-CrO催化剂，减压除去空气后，通入氢气，直至氢气压力达到约13.7MPa，搅拌下加热至255℃进行反应，直至氢气不再吸收为止。反应过程中，氢气压力下降，应随时补充氢气并保持相应压力。大约需要6～12。冷却后，减压至常压，倒出反应液。用95%的乙醇冲洗反应釜。加入25mL(40%)的氢氧化钠溶液，回流2h以分解未反应的酯。蒸馏，直至蒸汽温度达到95℃以除去乙醇。剩余物用乙醚进行连续提取法提取^①。蒸出乙醚和可能残余的乙醇，最后减压蒸馏，收集146～149℃/2.25kPa的馏分，得1,6-己二醇(1)52g，冷后固化，mp41～42℃，收率88%。注：①连续提取约40h，以保障提取完全。

^4..制法：

于高压反应釜中加入己二酸二乙酯(2)101g(0.52mol),10gCu-CrO催化剂，密闭反应釜，用氢气置换空气后，通入氢气至压力13.7MPa，搅拌下尽可能快地加热至255℃，并保持此温度直至氢气吸收完全。约6～12h。冷却，降压，停止搅拌。打开反应釜，倒出反应液，乙醇洗涤反应釜。过滤除去催化剂。滤液中加入25mL（40%）的氢氧化钠溶液，回流2h以水解未反应的酯。蒸馏，直至蒸汽温度达到95℃以除去乙醇。剩余物加入25mL水，于是取器中用乙醚连续提取(36～48h)。蒸出乙醚和残存的乙醇后，减压蒸馏，收集146～149℃/2.36kPa的馏分，冷后固体，得产物(1)52g，mp41～42℃，收率88%。

5.制法：

于装有搅拌器、滴液漏斗、回流冷凝器(顶部装氯化钙干燥管)的干燥的反应瓶中，加入四氢铝锂10.5(0.263mol),300mL用金属钠干燥的乙醚，搅拌10min，四氢铝锂不全溶。慢慢滴加由新蒸馏的己二酸二乙酯(2)50.5g(0.25mol)溶于150mL无水乙醚的溶液，控制滴加速度，使反应液保持回流。反应体系逐渐变粘稠，注意酚4次各加入50mL无水乙醚，以便于搅拌。加完后继续搅拌反应10min。慢慢滴加75mL水，或者加入22g乙酸乙酯以分解四氢铝锂。过滤，无水硫酸镁干燥，旋转蒸出乙醚，得无水粘稠物18.5g，冷后固化，mp41～42℃，为纯的1,6-己二醇(1)。滤饼溶于20%的硫酸中，乙醚提取6次，或者用乙醚连续提取，蒸出乙醚后，得6g产物，mp41～42℃，共得产物(1)24.5g,收率91%。

1,6-己二醇海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

1,6-己二醇文献

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