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己二酸二甲酯

己二酸二甲酯用途

【用途一】
用作合成中间体，高沸点溶剂等
【用途二】
用于有机合成，作增塑剂。
【用途三】
气相色谱对比样品，增塑剂，有机合成。

己二酸二甲酯名称

[ CAS 号 ]:
627-93-0

[ 中文名 ]:
己二酸二甲酯

[ 英文名 ]:
Dimethyl adipate

[中文别名 ]:

[英文别名 ]:

EINECS 211-020-6
MFCD00008469
dimethyl hexanedioate

己二酸二甲酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
228.7±0.0 °C at 760 mmHg

[ 熔点 ]:
8 °C(lit.)

[ 分子式 ]:
C₈H₁₄O₄

[ 分子量 ]:
174.194

[ 闪点 ]:
107.2±0.0 °C

[ 精确质量 ]:
174.089203

[ PSA ]:
52.60000

[ LogP ]:
1.03

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.423

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acids, bases reducing agents.

[ 水溶解性 ]:
水溶性：不溶；水溶解度：600 mg/l ；可溶于：乙醚,醇

己二酸二甲酯MSDS

己二酸二甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AV1645000

CHEMICAL NAME :: Adipic acid, dimethyl ester

CAS REGISTRY NUMBER :: 627-93-0

BEILSTEIN REFERENCE NO. :: 1707443

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H14-O4

MOLECULAR WEIGHT :: 174.22

WISWESSER LINE NOTATION :: 1OV4VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1809 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,1596,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 362 mg/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,1596,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 181 mg/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,1596,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1493 No. of Facilities: 2425 (estimated) No. of Industries: 18 No. of Occupations: 25 No. of Employees: 24766 (estimated) No. of Female Employees: 3381 (estimated)

己二酸二甲酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
AV1645000

[ 海关编码 ]:
29171290

己二酸二甲酯合成路线

己二酸二甲酯上下游产品

己二酸二甲酯上游产品

己二酸二甲酯下游产品

己二酸二甲酯制备

由己二酸与甲醇在硫酸存在下酯化而得。

己二酸二甲酯海关

[ 海关编码 ]: 2917120090

[ 中文概述 ]:
2917120090. 己二酸及其盐和酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2917120090. adipic acid and its salts. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

己二酸二甲酯文献

Mixture risk assessment: a case study of Monsanto experiences.

Food Chem. Toxicol. 34(11-12) , 1139-45, (1996)

Monsanto employs several pragmatic approaches for evaluating the toxicity of mixtures. These approaches are similar to those recommended by many national and international agencies. When conducting ha...

Carboxylesterase-dependent cytotoxicity of dibasic esters (DBE) in rat nasal explants.

Toxicol. Appl. Pharmacol. 107(2) , 285-301, (1991)

Dibasic esters (DBE) are a solvent mixture of dimethyl adipate (DMA), dimethyl glutarate (DMG), and dimethyl succinate (DMS) used in the paint and coating industry. Subchronic inhalation toxicity stud...

Metabolism of dibasic esters by rat nasal mucosal carboxylesterase.

Drug Metab. Dispos. 19(1) , 124-9, (1991)

Inhalation exposure of rats to dibasic esters revealed lesions of the nasal olfactory epithelium similar to those observed with other ester solvents. Female rats are more sensitive to these effects th...

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