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TBPB

TBPB用途

TBPB是M1 mAChR变构激动剂，EC50值为289nM，调节amyloid的加工和小鼠体内具有抗精神病药物等活性。

TBPB名称

[ CAS 号 ]:
634616-95-8

[ 中文名 ]:
TBPB

[ 英文名 ]:
TBPB

[英文别名 ]:

2-Pyrrolo-1,3,2-dioxa-phospholan
2-pyrrol-1-yl-1,3,2-dioxaphospholan
TBPB

TBPB生物活性

[ 描述 ]:

TBPB是M1 mAChR变构激动剂,EC50值为289nM,调节amyloid的加工和小鼠体内具有抗精神病药物等活性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Jones CK, et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008 Oct 8;28(41):10422-33.

[2]. Miller NR, et al. Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5443-7.

[相关活性小分子]

TBPB物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 分子式 ]:
C₂₅H₃₂N₄O

[ 分子量 ]:
404.548

[ 精确质量 ]:
404.257599

[ PSA ]:
44.53000

[ LogP ]:
4.96

[ 折射率 ]:
1.623

[ 储存条件 ]:
2-8℃

TBPB安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

TBPB合成路线

详细合成路线

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TBPB文献

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