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6-羟基多巴胺氢溴酸盐

6-羟基多巴胺氢溴酸盐用途

【用途一】
生化试剂，可诱发帕金森病大鼠模型。

6-羟基多巴胺氢溴酸盐名称

[ CAS 号 ]:
636-00-0

[ 中文名 ]:
6-羟基多巴胺合溴化氢

[ 英文名 ]:
6-HYDROXYDOPAMINE HYDROBROMIDE

[中文别名 ]:

[英文别名 ]:

5-(2-aminoethyl)benzene-1,2,4-triol,hydrobromide
EINECS 211-247-0
MFCD00012894
Oxidopamine (hydrobromide)

6-羟基多巴胺氢溴酸盐生物活性

[ 描述 ]:

Oxidopamine hydrobromide是一个有选择性的含有儿茶酚胺的神经毒素,通过神经元的传输机制吸收和积累降低大脑儿茶酚胺水平。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

[参考文献]

[1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.

[2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.

[相关活性小分子]

6-羟基多巴胺氢溴酸盐物理化学性质

[ 沸点 ]:
406ºC at 760 mmHg

[ 熔点 ]:
216-220 °C(lit.)

[ 分子式 ]:
C₈H₁₂BrNO₃

[ 分子量 ]:
250.090

[ 闪点 ]:
199.3ºC

[ 精确质量 ]:
249.000046

[ PSA ]:
86.71000

[ LogP ]:
1.96300

[ 外观性状 ]:
solid | tan to brown

[ 储存条件 ]:
2-8°C

6-羟基多巴胺氢溴酸盐MSDS

详细MSDS(安全技术说明书)

6-羟基多巴胺氢溴酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC4600000

CHEMICAL NAME :: 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide

CAS REGISTRY NUMBER :: 636-00-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H11-N-O3.Br-H

MOLECULAR WEIGHT :: 250.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 21-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male Reproductive - Maternal Effects - parturition

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 76,415,1986

6-羟基多巴胺氢溴酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DC4600000

[ 海关编码 ]:
2922299090

6-羟基多巴胺氢溴酸盐上下游产品

6-羟基多巴胺氢溴酸盐上游产品

6-羟基多巴胺氢溴酸盐下游产品

6-羟基多巴胺氢溴酸盐海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

6-羟基多巴胺氢溴酸盐文献

Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.

J. Neuropathol. Exp. Neurol. 73(8) , 770-9, (2014)

Chronic degeneration of nigrostriatal projections, followed by nigral dopaminergic cell death, is a key feature of Parkinson disease (PD). This study examines the neuroprotective potential of the rho ...

Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells.

Phytother Res. 28(4) , 611-6, (2014)

6-Hydroxydopamine (6-OHDA) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to ap...

Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice.

Eur. Rev. Med. Pharmacol. Sci. 17(10) , 1360-8, (2013)

Inflammation and oxidative stress are believed to contribute to neuronal degeneration of the nigrostriatal dopaminergic (DA) pathway in Parkinson's disease. Curcumin, a component of the yellow curry s...

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