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sodium folate

sodium folate用途

叶酸(维生素B9)钠是一种口服活性必需营养素,来自B族复合维生素。叶酸钠具有抗抑郁作用。叶酸钠可降低新生儿神经管缺陷的风险。叶酸钠可用于治疗因叶酸缺乏引起的巨幼细胞和大细胞贫血[1][2][3][4]。

sodium folate名称

[ CAS 号 ]:
6484-89-5

[ 英文名 ]:
sodium folate

sodium folate生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 神经疾病

[ 靶点 ]

Microbial Metabolite

[体外研究]

叶酸钠在防止染色体断裂和DNA低甲基化方面起着关键作用[1]。

[体内研究]

叶酸钠(10、50、100 mg/kg；p.o.)在该行为小鼠模型中显示出抗抑郁作用[2]。叶酸钠(1,10 nmol/位点)在习惯于新环境的小鼠中没有显示出精神刺激作用[2]。叶酸钠(1,5 mg/kg；p.o.)可防止大鼠后代肝脏基因表达的表观遗传修饰[3]。动物模型：30-40 g瑞士小鼠[2]剂量：10、50、100 mg/kg给药：P.o.结果：减少强迫游泳试验(FST)中的不动时间(F324=11.21),并对尾部悬吊试验(TST)中不动时间产生显著影响(F3,20=5.71)。动物模型：30-40g瑞士小鼠[2]剂量：1-10nmol/部位给药：静脉注射。结果：减少小鼠在FST(F3,22=12.31)和TST(F33,22=5.50)中的不动时间。动物模型：处女雌性Wistar大鼠[3]剂量：1,5 mg/kg(180 g/kg蛋白质加1 mg/kg叶酸或90 g/kg酪蛋白加1,5 g/kg叶氨酸)给药：P.o.结果：预防表观生长

[参考文献]

[1]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8.

[2]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73.

[3]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6.

[4]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48.

sodium folate物理化学性质

[ 分子式 ]:
C₁₉H₁₈N₇NaO₆

[ 分子量 ]:
463.37900

[ 精确质量 ]:
463.12200

[ PSA ]:
216.11000

sodium folate毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LP5700000

CHEMICAL NAME :: Folic acid, monosodium salt

CAS REGISTRY NUMBER :: 6484-89-5

LAST UPDATED :: 198909

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H18-N7-O6.Na

MOLECULAR WEIGHT :: 463.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 526 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 631 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 431 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 126 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 48,289,1946