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4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯

用途

SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。

名称

[ CAS 号 ]:
64987-85-5

[ 中文名 ]:
4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯

[ 英文名 ]:
N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate

[中文别名 ]:

[英文别名 ]:

MFCD00009634

生物活性

[ 描述 ]:

SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
501.7±42.0 °C at 760 mmHg

[ 熔点 ]:
180-182 °C(lit.)

[ 分子式 ]:
C₁₆H₁₈N₂O₆

[ 分子量 ]:
334.324

[ 闪点 ]:
257.2±27.9 °C

[ 精确质量 ]:
334.116486

[ PSA ]:
101.06000

[ LogP ]:
-0.39

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: 50 mg/mL

MSDS

安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

合成路线

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[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

文献

A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells.

J. Immunol. Res. 2015 , 561814, (2015)

Antibody-drug conjugates (ADCs) have evolved as a new class of potent cancer therapeutics. We here report on the development of ADCs with specificity for the B-cell lineage specific (surface) antigen ...

Solid formulations by a nanocrystal approach: critical process parameters regarding scale-ability of nanocrystals for tableting applications.

Int. J. Pharm. 485 , 77-86, (2015)

Nanocrystallization is among the foremost drug delivery platform approaches for the commercial development of poorly soluble drugs. There exists an urge to enable a universal shift of the production o...

An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates.

Nanoscale 7 , 12614-24, (2015)

Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica ...

更多文献

4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

上下游产品

上游产品

下游产品

海关

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