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Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate用途

硫酸脱氢表雄酮是一种神经活性神经甾体,通过影响神经元的迁移、树突的树状化和新突触的形成,在大脑发育和衰老中发挥重要作用[1][2][3]。

Dehydroepiandrosterone sulfate名称

[ CAS 号 ]:
651-48-9

[ 中文名 ]:
硫酸脱氢表雄酮

[ 英文名 ]:
10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene

[英文别名 ]:

Dehydroepiandrosterone 3-sulfate
dehydroepiandrosterone 3β-sulfate
[3H]-Dehydroepiandrosterone 3-sulfate
DHEA-sulphate
ANDROST-5-EN-17-ONE,3-(SULFOOXY)-, (3B)-
dehydroepiandrosterone 3-sulphate
DHEA sulfate

Dehydroepiandrosterone sulfate生物活性

[ 描述 ]:

硫酸脱氢表雄酮是一种神经活性神经甾体,通过影响神经元的迁移、树突的树状化和新突触的形成,在大脑发育和衰老中发挥重要作用[1][2][3]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

硫酸脱氢表雄酮(DHEAS)选择性地增加含有树突标记MAP-2的神经轴突的长度[1]。据报道,硫酸脱氢表雄酮(DHEAS)直接应用于视前隔神经元时可增加神经元兴奋性(放电频率)[1]。脱氢表雄酮(DHEA)由人类肾上腺大量产生,主要作为3-磺基共轭DHEA硫酸盐(DS)在胎儿期产生[2]。硫酸脱氢表雄酮(DHEAS)通常无毒,即使长期服用也没有副作用[3]。

[体内研究]

DHEAS慢性给药对性能产生剂量依赖性影响[3]。动物模型：64只雄性Sprague-Dawley大鼠,大约90天大(300-400克)[3]。剂量：5、10或20 mg/kg。给药：术后7天和所有行为测试前1小时开始皮下注射。结果：与接受车辆的受伤大鼠相比,在改善到达平台的潜伏期方面显著有效。

[参考文献]

[1]. E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91.

[2]. C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7.

[3]. Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70.

Dehydroepiandrosterone sulfate物理化学性质

[ 密度 ]:
1.1763 g/ml

[ 熔点 ]:
190-192 °C (lit.)

[ 分子式 ]:
C₁₉H₂₈O₅S

[ 分子量 ]:
368.49

[ 精确质量 ]:
368.16600

[ PSA ]:
89.05000

[ LogP ]:
4.78710

[ 储存条件 ]:
20 °C，密封，干燥

Dehydroepiandrosterone sulfate毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8530000

CHEMICAL NAME :: Androst-5-en-17-one, 3-(sulfooxy)-, (3-beta)-

CAS REGISTRY NUMBER :: 651-48-9

LAST UPDATED :: 199604

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H28-O5-S

MOLECULAR WEIGHT :: 368.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 655 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 293 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 25200 ug/kg/28D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - effect on menstrual cycle Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 57,912,1992 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 mg/kg

SEX/DURATION :: female 39 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - biochemical and metabolic Endocrine - androgenic

REFERENCE :: NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 41,806,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993

Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate用途

Dehydroepiandrosterone sulfate名称

Dehydroepiandrosterone sulfate生物活性

Dehydroepiandrosterone sulfate物理化学性质

Dehydroepiandrosterone sulfate毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Dehydroepiandrosterone sulfate安全信息

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