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戊菌唑

戊菌唑用途

Penconazole 是一种典型的三唑类杀菌剂 (fungicide),主要用于苹果、葡萄、蔬菜等地的白粉病防治。Penconazole 抑制真菌固醇生物合成。Penconazole 降低大鼠大脑和小脑 AChE 活性。

戊菌唑名称

[ CAS 号 ]:
66246-88-6

[ 中文名 ]:
戊菌唑

[ 英文名 ]:
penconazole

[中文别名 ]:

[英文别名 ]:

topasmz
EINECS 266-275-6
PENCONAZOL
T5NN DNJ A1Y3&R BG DG
1-[2-(2,4-Dichlorophenyl)pentyl]-1H-1,2,4-triazole
onmex
MFCD00078737
Topas
topaze
topazec

戊菌唑生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[体内研究]

喷康唑(67mg/kg；静脉注射；9天内每隔2天)诱导大鼠大脑和小脑组织的氧化应激[2]。喷康唑具有诱导成年大鼠脑组织氧化损伤的能力,表现为脂质过氧化和蛋白质氧化的增加,以及酶和非酶抗氧化状态的扰动。喷康唑还影响胆碱能系统、膜结合atp酶活性和脑组织结构。喷康唑是一种潜在的神经毒性农药,通过产生氧化应激来发挥其神经毒性作用。喷康唑可显著抑制成年大鼠大脑(11%)和小脑(25%)的AChE活性[2]。动物模型：12只雄性Wistar大鼠[2]剂量：67mg/kg给药：I.p.；9天内每2天一次。结果：大脑和小脑的绝对重量和相对重量分别显著增加。

[参考文献]

[1]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8.

[2]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 2017;36(8):854-866.

戊菌唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
415.3±55.0 °C at 760 mmHg

[ 熔点 ]:
57.6-60.3ºC

[ 分子式 ]:
C₁₃H₁₅Cl₂N₃

[ 分子量 ]:
284.184

[ 闪点 ]:
204.9±31.5 °C

[ 精确质量 ]:
283.064301

[ PSA ]:
30.71000

[ LogP ]:
3.66

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.602

[ 储存条件 ]:
0-6°C

戊菌唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4615000

CHEMICAL NAME :: 1H-1,2,4-Triazole, 1-(2-(2,4-dichlorophenyl)pentyl)-

CAS REGISTRY NUMBER :: 66246-88-6

BEILSTEIN REFERENCE NO. :: 0541488

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H15-Cl2-N3

MOLECULAR WEIGHT :: 284.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,554,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984

戊菌唑安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H361d-H410

[ 警示性声明 ]:
P201-P273-P301 + P312 + P330-P308 + P313-P391-P501

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
XZ4615000

[ 海关编码 ]:
2933990015

戊菌唑合成路线

详细合成路线

戊菌唑上下游产品

戊菌唑上游产品

戊菌唑下游产品

戊菌唑海关

[ 海关编码 ]: 2933990016

[ 中文概述 ]:
2933990016. 环菌唑,叶菌唑,灭菌唑,种菌唑等〔包括申嗪霉素,氟喹唑,哒螨灵,喹螨醚,氟草敏,氟咯草酮〕. 增值税率:17.0%. 退税率:9.0%. 监管条件:S(进出口农药登记证明). 最低关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933990016 1-(2-(2,4-dichlorophenyl)pentyl)-1h-1,2,4-triazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

戊菌唑文献

The dissipation of three fungicides in a biobed organic substrate and their impact on the structure and activity of the microbial community.

Environ. Sci. Pollut. Res. Int. 20(4) , 2546-55, (2013)

Biopurification systems (BPS) have been introduced to minimise the risk for point source contamination of natural water resources by pesticides. Their depuration efficiency relies mostly on the high b...

Enantiomeric separation of triazole fungicides with 3-μm and 5-μml particle chiral columns by reverse-phase high-performance liquid chromatography.

Chirality 23(6) , 479-86, (2011)

This study used chiral columns packed with 3-μm and 5-μm particles to comparatively separate enantiomers of 9 triazole fungicides, and Lux Cellulose-1 columns with chiral stationary phase of cellulose...

Biological monitoring of pesticide exposures in residents living near agricultural land.

BMC Public Health 11 , 856, (2011)

There is currently a lack of reliable information on the exposures of residents and bystanders to pesticides in the UK. Previous research has shown that the methods currently used for assessing pestic...

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戊菌唑