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多沙唑嗪杂质F

多沙唑嗪杂质F用途

二氢速心律失常是维生素D的合成类似物。二氢速心律失常可用于研究低钙血症(血液中缺乏钙)和甲状旁腺功能减退(体内缺乏甲状旁腺激素)[1][2]。

多沙唑嗪杂质F名称

[ CAS 号 ]:
67-96-9

[ 中文名 ]:
双氢速甾醇

[ 英文名 ]:
HSDB 3314

[中文别名 ]:

[英文别名 ]:

Dihydrotachysterin2
AT-10
ANTITANIL
Dygrayl
parterol
MFCD00867069
dygratyl
Tachyrol
DIHYDROTACHYSTEROL
dihydral

多沙唑嗪杂质F生物活性

[ 描述 ]:

二氢速心律失常是维生素D的合成类似物。二氢速心律失常可用于研究低钙血症(血液中缺乏钙)和甲状旁腺功能减退(体内缺乏甲状旁腺激素)[1][2]。

[ 相关类别 ]:

信号通路 >> 维生素 D 相关 >> VD/VDR

研究领域 >> 代谢疾病

[体外研究]

在缺乏甲状旁腺激素和功能性肾组织的情况下,二氢速调素通过刺激肠道钙吸收和动员骨钙而有效地提高血钙[1]。二氢速调甾醇也会增加肾磷酸盐排泄[1]。

[体内研究]

二氢速调甾醇是一种有效的合成维生素D类似物,可广泛获得,但比维生素D2更昂贵。它的起效期和半衰期介于维生素D2和骨化三醇之间。二氢速调素(最初以0.03至0.08 mg/kg/天的剂量给药,持续2至3天。最终剂量范围为0.004至0.04 mg/kg/天)对甲状旁腺机能减退症的治疗有用[2]。动物模型：动物模型：五只混合饲养的中青年猫[2]剂量：最初剂量为0.03至0.08 mg/kg/天,持续2至3天。最终剂量范围为0.004至0.04 mg/kg/天。给药：口服给药结果：有助于治疗甲状旁腺功能减退症。

[参考文献]

[1]. I Quack, et al. Dihydrotachysterol therapy for hypoparathyroidism: consequences of inadequate monitoring. Five cases and a review. Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):376-80.

[2]. M E Peterson, et al. Idiopathic hypoparathyroidism in five cats. J Vet Intern Med. Jan-Feb 1991;5(1):47-51.

多沙唑嗪杂质F物理化学性质

[ 密度 ]:
1.003 g/cm3

[ 沸点 ]:
499.5ºC at 760 mmHg

[ 熔点 ]:
131ºC

[ 分子式 ]:
C₂₈H₄₆O

[ 分子量 ]:
398.66400

[ 闪点 ]:
217.6ºC

[ 精确质量 ]:
398.35500

[ PSA ]:
20.23000

[ LogP ]:
7.72090

[ 折射率 ]:
1.569

[ 储存条件 ]:
-20°C

多沙唑嗪杂质FMSDS

详细MSDS(安全技术说明书)

多沙唑嗪杂质F毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WW0600000

CHEMICAL NAME :: Tachysterol, dihydro-

CAS REGISTRY NUMBER :: 67-96-9

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C28-H46-O

MOLECULAR WEIGHT :: 398.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 288 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,330,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,330,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 150 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 41,181,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5329 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 403 (estimated) No. of Female Employees: 189 (estimated)

多沙唑嗪杂质F安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
WW0600000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

多沙唑嗪杂质F合成路线

详细合成路线

多沙唑嗪杂质F文献

Prevalence and correction of 25(OH) vitamin D deficiency in peritoneal dialysis patients.

Perit. Dial. Int. 25(4) , 362-6, (2005)

Peritoneal dialysis (PD) patients are at risk for 25(OH) vitamin D deficiency due to effluent loss in addition to traditional risk factors.To measure 25(OH) vitamin D deficiency in prevalent PD patien...

3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells.

Brain Res. Mol. Brain Res. 133(2) , 215-23, (2005)

3-nitropropionic acid (3-NPA), a complex II inhibitor of the electron transport chain, causes Huntington disease-like symptoms after administration into animals. However, primary mechanisms of cell de...

Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.

Biochem. Biophys. Res. Commun. 303(1) , 52-8, (2003)

Vitamin D-elicited hypercalcemia/hypercalciuria is associated with polyuria in humans and in animal models. In rats, dihydrotachysterol (DHT) induces AQP2 water channel downregulation despite unaltere...

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