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伐诺司林二盐酸盐

伐诺司林二盐酸盐用途

Vanoxerine dihydrochloride是有效,选择性的多巴胺再摄取抑制剂。

伐诺司林二盐酸盐名称

[ CAS 号 ]:
67469-78-7

[ 中文名 ]:
伐诺司林二盐酸盐

[ 英文名 ]:
Vanoxerine dihydrochloride

[中文别名 ]:

伐洛司林二盐酸盐

[英文别名 ]:

Vanoxerine dihydrochloride
MFCD00055193
Vanoxerine hydrochloride
Vanoxerine (dihydrochloride)

伐诺司林二盐酸盐生物活性

[ 描述 ]:

Vanoxerine dihydrochloride是有效,选择性的多巴胺再摄取抑制剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 多巴胺转运蛋白

研究领域 >> 神经疾病

[参考文献]

[1]. Lacerda AE, et al. Vanoxerine: cellular mechanism of a new antiarrhythmic. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.

[2]. Mahmud F, et al. Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue. Chaos. 2011 Jun;21(2):023121.

[相关活性小分子]

伐诺司林二盐酸盐物理化学性质

[ 沸点 ]:
542.7ºC at 760 mmHg

[ 熔点 ]:
221 °C

[ 分子式 ]:
C₂₈H₃₄Cl₂F₂N₂O

[ 分子量 ]:
523.485

[ 闪点 ]:
282ºC

[ 精确质量 ]:
522.201599

[ PSA ]:
15.71000

[ LogP ]:
6.80100

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

伐诺司林二盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

伐诺司林二盐酸盐合成路线

详细合成路线

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伐诺司林二盐酸盐文献

Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates.

Int. J. Neuropsychopharmacol. , 1-15, (2011)

Impaired top-down regulation of the amygdala, and its modulation by serotonin (5-HT), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders...

Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.

J. Pharmacol. Exp. Ther. 335(1) , 124-32, (2010)

Most life-long drug addiction begins during adolescence. Important structural and functional changes in brain occur during adolescence and developmental differences in forebrain dopamine systems could...

Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania.

Psychopharmacology 225(3) , 661-74, (2013)

The Iowa Gambling Task (IGT) can be used to quantify impulsive and risky choice behaviors in psychiatric patients, e.g., bipolar disorder (BD) sufferers. Although developing treatments for these behav...

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